ADO Den Haag and Heerenveen will join Vitesse and Utrecht in the play-offs for the last Europa League spot despite mixed fortunes on the final day.
Former Eredivisie champions FC Twente have been relegated from the league after a thumping 5-0 defeat at Vitesse on Sunday.
Bottom club FC Twente boosted their Eredivisie survival hopes with a 2-0 home win over PEC Zwolle.
Bryan Linssen scored twice in the second half as Vitesse won 7-0 against 10-man Sparta Rotterdam on Saturday.
PSV Eindhoven maintained their dominance of the Eredivisie with a 5-1 win over NAC Breda on Saturday.
Bjorn Johnsen scored twice in the second half as ADO Den Haag came from behind to win 2-1 at Excelsior in the Eredivisie on Friday.
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