Neil Robertson crashed out of the UK Championship and also saw his hopes of qualifying for next month's Masters brought to an end after defeat in York.
Robertson lost a third-round thriller 6-5 to world No 42 Mark Joyce, who produced a superb clearance to pink of 42 in the deciding frame to move through to round four.
The Australian two-time former UK champion needed to win to retain any hope of qualifying for the lucrative top-16 event, which he is now destined to miss for the first time since 2006.
Earlier, Judd Trump became yet another big-name casualty when he was dumped out at the third-round stage by veteran Graeme Dott.
Former world champion Dott, now down at 30 in the world rankings, reeled off six consecutive frames to win 6-2 and set up a fourth-round meeting with fellow Scot Stephen Maguire.
With Trump, reigning champion Mark Selby and Ding Junhui all crashing out in the early rounds, Ronnie O'Sullivan is the top-ranked player left in the competition.
I just felt so comfortable out there, it's nice to be back playing on TV.
Dott told worldsnooker.com: "You've got to try and attack Judd and that is what I did at every chance. I just felt so comfortable out there, it's nice to be back playing on TV.
"I get asked the same questions like, 'are you still playing snooker?' by people like the delivery men and I say, 'yeah I'm still playing, still trying'. So it's nice to show people that I can actually play the game."
Stephen Maguire edged a 6-5 victory over 2015 finalist Liang Wenbo, while Ryan Day also wriggled through an all-Welsh battle with Mark Williams in a decider.
Mark Allen finished with a break of 119 as he beat Peter Lines 6-4, but Marco Fu was another significant casualty as he fell to China's Lyu Haotian by the same score.
Watch the Mosconi Cup live on Sky Sports Action between December 4-7.