Crotone beat Lazio 3-1 on the final day to ensure survival, as Empoli went down after losing at already-relegated Palermo.
Napoli took advantage of Roma's derby defeat to close to within one point of second place in Serie A with victory over Inter Milan.
Mauro Icardi scored a hat-trick but Inter Milan lost 5-4 to Fiorentina in a thrilling Serie A match in Florence.
Juve extended their lead at the top of Serie A after beating Pescara 2-0 to strengthen their grip on a sixth straight Scudetto title.
Juventus' Gonzalo Higuain failed to score on his long-awaited return to Napoli as the game ended 1-1, while Crotone beat Chievo.
Chelsea loanee Juan Cuadrado was the hero for Juventus on a busy day of Serie A action, with Roma and Napoli also victorious.