An official statement from Cricket Australia chief executive James Sutherland said: "Michael Hussey has been a vital contributor to many Australian team wins over his very successful Test cricket career.
"Affectionately known as 'Mr Cricket', he has always been thoroughly committed to meticulous preparation and the highest levels of physical fitness which have in turn delivered consistent performances in all forms of the game.
"An incredibly reliable player and leader within the Australian cricket team, Michael will retire from Test cricket with a record that puts him amongst the very best Australian batsmen of all time.
"Beyond his contributions to team success, he will be remembered for the way he has carried himself on and off the field - and in doing so he has won the respect and admiration of players, officials and fans all around the world.
"In congratulating him on a great Test career, we wish him well and hope to see him stay close to the game after his playing days are over."