Pakistan will try to seal their first one-day international series victory over South Africa at Port Elizabeth.
Misbah-ul Haq admits Pakistan's ODI thrashing by South Africa is a worrying sign ahead of the 2015 World Cup.
AB de Villiers' century helped South Africa complete a 4-1 one-day series win over Pakistan in Sharjah.
Quinton de Kock's maiden one-day century helped South Africa clinch the series against Pakistan in Abu Dhabi.
South Africa clinched a 68-run victory over Pakistan to move 2-1 ahead in the five-match one-day international series.
South Africa batsman Graeme Smith will miss the rest of the one-day international series against Pakistan.
Pakistan have levelled the one-day series against South Africa after beating the Proteas by 66 runs in Dubai.
South Africa snatched victory from the jaws of defeat in Sharjah after Pakistan collapsed in a low-scoring thriller.
South Africa paceman Dale Steyn will be rested for the first two one-day internationals against Pakistan.
Pakistan have recalled Mohammad Hafeez to their squad for their upcoming five-match one-day series against South Africa.