Fernando Torres scored his 100th Atletico Madrid goal in a 3-1 comeback win at home to Eibar, as Villarreal held Athletic Bilbao.
Crystal Palace are bottom of the Europe-wide form table - and only one Premier League team makes the top 10.
Gary Neville's winless streak in La Liga as Valencia boss was extended to seven games despite a late equaliser in a 1-1 draw at Deportivo.
Second-tier Mirandes caused an upset by knocking Deportivo La Coruna out of the Copa del Rey as Sevilla won their tie.
Athletic Bilbao fought back from a two-goal deficit to beat Villarreal, while Atletico Madrid were held by Rayo Vallecano.
Bruno Soriano's stoppage-time penalty secured a 2-1 win for Villarreal at Deportivo to strengthen their hold on fourth.
Updates from Zinedine Zidane's first match in charge of Real Madrid against Deportivo. Watch live on Sky Sports 1 HD.
There were wins for Deportivo and Espanyol as Valencia draw with Getafe and Real Betis held Sevilla in La Liga.
Sevilla eased through to the last-16 of the Copa del Rey by beating Logrones 2-0 at home in the second leg of their tie.
Barcelona throw away two-goal lead against Deportivo to draw 2-2 and miss opportunity to increase lead at the top of La Liga.
A recap from the Camp Nou as Barcelona are held to a dramatic draw by Deportivo.
Celta Vigo returned to the top four in La Liga on Saturday while Deportivo La Coruna extended their unbeaten run.
Real Sociedad pulled clear of the La Liga relegation zone with a 2-0 win over Sevilla.
Valencia hit five to beat high-flying Celta Vigo, while Eibar continued their rise up La Liga with victory over Getafe.
Atletico Madrid missed the chance to climb to the top of La Liga after drawing 1-1 with Deportivo on Friday night.
Atletico Madrid are ready to challenge for La Liga title this season, according to manager Diego Simeone.
Sevilla thrashed Getafe 5-0 in La Liga on Saturday night, while Granada drew with Real Betis and Malaga saw off Deportivo.
Barcelona and Real Madrid will start their Copa del Rey campaigns against third-tier clubs.
A hat-trick from Brazilian striker Charles saw Malaga beat David Moyes' Real Sociedad 3-1 and get off the winning mark this season.
In his live Q&A, Sky Sports Guillem Balague said there is no interest from Barcelona in Liverpool's Philippe Coutinho.