Valencia beat Leganes 3-1 in the first leg of their Copa del Rey fourth-round clash, while Espanyol came from behind to draw.
Sevilla came from 2-0 down to beat Deportivo La Coruna 3-2 at the Estadio Riazor, while Eibar won 1-0 at home to Celta Vigo.
Atletico Madrid's La Liga title hopes suffered another serious setback thanks to a 2-0 defeat to Real Sociedad on Saturday.
We look ahead to another eye-catching round of fixtures in La Liga, including champions Barcelona's trip to Sevilla.
Ivan Ramis and Pedro Leon goals helped Eibar win 2-1 and hand Villarreal their first defeat of the new La Liga season.
Real Sociedad recovered from losing to Basque rivals Bilbao last weekend to see off Alaves in a 3-0 win on Saturday evening.
Osasuna beat Eibar 3-2 at the Ipurua Municipal Stadium to claim their first La Liga win of the season.
Barcelona begin their Copa del Rey defence against Hercules, while Real face a trip to Leon to take on Cultural y Deportiva Leonesa.
Gareth Bale scored his 50th La Liga goal but Real Madrid were forced to settle for a 1-1 draw against Eibar.
Guillem Balague on Real Madrid's struggles, Barcelona's mistakes, Atletico Madrid's change of approach and your questions...
Relive the action as Real Madrid were held to a 1-1 draw by Eibar in La Liga.
Athletic Bilbao ended Sevilla's unbeaten start in La Liga with a 3-1 victory at San Mames, while Eibar beat Real Sociedad 2-0.
Argentine international Gabriel Mercado bundled home the winner as Sevilla moved up to second in La Liga with a 1-0 win over rivals Real Betis.
Antoine Griezmann scored twice as Atletico Madrid beat Sporting Gijon 5-0 in La Liga on Saturday.
Valencia's wretched start to the campaign continued as they suffered a third straight La Liga defeat at home to Real Betis.
Jon Driscoll and Terry Gibson return for an in-depth take on all the action and major talking points in La Liga.
Atletico Madrid were held to a goalless draw by Leganes on Saturday, while Valencia lost to Eibar.
Fulham have made a bid in the region of £3.5m for Eibar forward Sergi Enrich, Sky sources understand.
The 21st season of live Spanish football on Sky Sports gets underway this weekend with over 300 games available throughout the campaign.
Transfer sagas, managerial changes, new faces, old problems - Guillem Balague previews the new La Liga season.