Crotone beat Lazio 3-1 on the final day to ensure survival, as Empoli went down after losing at already-relegated Palermo.
Napoli took advantage of Roma's derby defeat to close to within one point of second place in Serie A with victory over Inter Milan.
Juventus took a giant leap towards securing an historic sixth consecutive Serie A title by thrashing hapless Genoa 4-0 in Turin.
Juve extended their lead at the top of Serie A after beating Pescara 2-0 to strengthen their grip on a sixth straight Scudetto title.
Gonzalo Higuain was the hero again as Juventus took another step towards the Serie A title with a 2-0 victory over Chievo.
Edin Dzeko set a new club record for Roma with both goals in a 2-0 victory over Empoli at the Stadio Olympico, as Lazio beat Sassuolo.
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