Granada slumped to a seventh straight defeat under boss Tony Adams, losing 2-1 at home to Espanyol in their final match of the season.
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Osasuna won the battle of the basement clubs, while Jose Gaya's second-half goal gave Valencia a 1-0 away win at Espanyol.
Barcelona leapfrogged Real Madrid to the top of La Liga with a 3-0 win over Espanyol in the Catalan Derby.
Can Barcelona keep their title push on track against local rivals Espanyol? Follow our live updates or watch on Sky Sports 2.
Barcelona boss Luis Enrique has backed the returning Neymar to boost his side's La Liga title hopes ahead of Saturday's derby with Espanyol.
Tony Adams saw his Granada side pushed closer towards relegation, while Atletico Madrid suffered a rare defeat.
The Barcelona derby becomes the focus of the La Liga title tussle on Saturday night.
Antoine Griezmann scored his 100th career goal in Spain as Atletico Madrid beat Espanyol 1-0 on Saturday.
Valencia's good form continued as they held high-flying Sevilla to a goalless draw in La Liga.
Diego Simeone will stay with Atletico Madrid, says Guillem Balague in his weekly Q&A and chats Tony Adams, David de Gea and Toni Kroos.
Sevilla were celebrating victory for the first time in over a month after beating Deportivo La Coruna 4-2 in La Liga.
A Filipe Luis goal kept Atletico Madrid's winning run going as they beat Real Sociedad 1-0.
Jose Antonio Reyes fired Espanyol to a late, 2-1 turnaround La Liga victory over Real Betis.
Watch and vote from the best strikes from around the world, including a superb free-kick from Ajax’s Lasse Schone.
Brazilian forward Deyverson netted the winner as Alaves beat Basque rivals Real Sociedad 1-0 at Mendizorroza.
Who would make your La Liga best XI if you could only pick one player per team? Check out WhoScored.com's verdict.
Espanyol twice threw away the lead but recovered to beat Las Palmas 4-3 in a thrilling La Liga encounter on Friday night.
Villarreal kept alive their top-four hopes in La Liga with a 2-0 triumph over Espanyol at the Estadio de la Ceramica.