Liverpool will face Italian side Atalanta in the Europa League quarter-finals, while West Ham take on Xabi Alonso's Bayer Leverkusen.
Sky Sports' football writers assess a busy night of Europa League and Europa Conference League action.
Liverpool eased into the Europa League quarter-finals after demolishing Sparta Prague 6-1 at Anfield to win the tie 11-2 on aggregate.
The UEFA coefficient rankings could see Scotland lose their automatic Champions League spot - but how might it all change?
UEFA is making contingency plans for the "extremely challenging" possibility of a Liverpool vs Rangers Europa League final in Dublin in May.
Brighton's Europa League campaign came to an end despite Roberto De Zerbi's side finishing on a high with a 1-0 victory over Roma at the Amex Stadium.
Rangers crashed out of the Europa League after a 1-0 home defeat to Benfica, exiting Europe's second-tier competition 2-3 on aggregate.
Mohammed Kudus' wonder double rounded off a superb evening for West Ham, who breezed into the Europa League quarter-finals with a 5-1 aggregate win over Freiburg.
Jurgen Klopp has refuted claims that incoming Liverpool chief Michael Edwards asked him to stay on as boss.
Liverpool warmed up for Sunday's huge Premier League game with Man City in fine fashion as they got a 5-1 first-leg lead over Sparta Prague in the Europa League last 16.
Sky Sports' football writers assess a busy night of Europa League and Europa Conference League action, with five British teams facing mixed fortunes.
Brighton's Europa League hopes were left hanging by a thread after a 4-0 thrashing by Roma in their last-16 first leg left them with a mountain to climb at the Amex.
West Ham lost their Europa League last 16 first-leg tie to Freiburg, beaten 1-0 in Germany, but there was late VAR drama that denied the Hammers a penalty.
Ten-player Aston Villa held out for a 0-0 draw against a relatively inexperienced Ajax side at the Johan Cruyff Arena, who were also reduced to 10 late on.
Rangers twice led at the Estadio da Luz before the Portuguese side staged a comeback to leave the Europa League last-16 tie delicately poised at 2-2.
Liverpool have been drawn with Sparta Prague in the last-16 draw of the Europa League while Brighton face a trip to AS Roma in their first leg.
Rounding up all of Thursday's action as the Europa League and Europa Conference League last-16 line-ups were confirmed....
Romelu Lukaku secured a 1-1 draw for Roma at Feyenoord in the first leg of their Europa League knockout round play-off.
Man Utd, Man City, Chelsea, Spurs, Arsenal and Liverpool have ruled out joining the European Super League.
The Premier League are in pole position for an additional Champions League place next season.