PEC Zwolle moved up to second in the Eredivisie after a 2-0 win at struggling NAC Breda on Saturday.
Rene Hake has stood down as FC Twente's head coach after a poor start to the season.
PSV Eindhoven extended their lead at the top of the Eredivisie to five points with a 5-2 win at VVV-Venlo.
FC Twente moved out of the bottom three in the Eredivisie with a 2-1 derby win against Heracles on Friday.
Jurgen Locadia scored four goals as PSV Eindhoven trounced FC Utrecht 7-1 to climb to the top of the Eredivisie table.
Champions Feyenoord saw their 100 per cent start to the Eredivisie season end with a 1-0 defeat at PSV Eindhoven.
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