Chelsea loanee Juan Cuadrado was the hero for Juventus on a busy day of Serie A action, with Roma and Napoli also victorious.
Mauro Icardi and Ever Banega scored hat-tricks as Inter Milan thrashed Atalanta 7-1 in Serie A on Sunday.
Juventus now lead Serie A by eight points after drawing 1-1 at Udinese on Sunday, while Lazio and Inter Milan both claimed away wins.
Lyon cruised through to the last 16 of the Europa League with a thumping 11-2 aggregate win over AZ Alkmaar.
Edin Dzeko hit a 21-minute hat-trick as Roma took a 4-0 first-leg advantage in their Europa League last-32 tie against Villarreal.
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Edin Dzeko moved top of the Serie A scoring charts after netting twice in Roma's 4-0 win over Fiorentina on Tuesday.
Gonzalo Higuain reached 15 goals for the Serie A season as Juventus reinforced their position as leaders with a 2-0 win over Sassuolo.
Mauro Zarate has joined Watford on a two-and-a-half year deal from Fiorentina.
A header from Jose Callejon fired Napoli into the semi-finals of the Coppa Italia during a bad-tempered 1-0 win over Fiorentina.
Mauro Zarate's arrival at Watford is being delayed until Fiorentina have played Napoli on Tuesday, Sky sources say.
Napoli extended their unbeaten run in Serie A to 10 games with a 2-1 victory over AC Milan at San Siro on Saturday.
Fiorentina forward Mauro Zarate will join Watford on loan until the end of the season in the next 48 hours.
Fiorentina put a dent in Juventus' title charge with a 2-1 win at the Stadio Artemio Franchi.
Serie A leaders Juventus returned from their winter break with a 3-0 dismantling of Bologna on Sunday night.
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Former Benfica, Fiorentina, AC Milan and Portugal midfielder Rui Costa chooses his #One2Eleven on The Fantasy Football Club.
Roma bounced back from their Serie A defeat to Juventus at the weekend by coming from behind to beat Chievo 3-1.
Radja Nainggolan punished AC Milan for missing a first-half penalty by firing Roma to a 1-0 Serie A victory on Monday.
Manchester United will face Saint-Etienne in the Europa League round of 32, while Spurs will take on Gent.