A rare goal from Kevin Strootman helped Roma reclaim second place in the Serie A table as they beat derby rivals Lazio 2-0 on Sunday.
Inter Milan held on to beat 10-man Fiorentina 4-2 and hand boss Stefano Pioli his first win since taking charge.
Inter Milan let a two-goal lead slip as they crashed out of the Europa League with a 3-2 defeat to Hapoel Be'er Sheva.
Roma lost further ground on Serie A leaders Juventus when they were sunk by a late penalty and lost 2-1 at Atalanta.
Juventus maintained their four-point lead at the top of the Serie A table after Miralem Pjanic struck a late winner at Chievo.
Aritz Aduriz netted five goals in Athletic Bilbao's 5-3 win over Genk in the Europa League on Thursday, as Ajax, Schalke, Shakhtar and Zenit all progressed.
Gonzalo Higuain's second-half winner saw Juventus clinch their 22nd consecutive home win in Serie A with a 2-1 victory over Napoli.
Joe Hart was at fault for Mauro Icardi's first goal as Inter Milan beat Torino 2-1 in Serie A on Wednesday.
Frank de Boer's future as Inter Milan head coach is under serious threat after a 2-1 defeat to Atalanta in Bergamo on Sunday.
Shakhtar Donetsk maintained their 100 per cent start to Europa League Group H as they thrashed Gent 5-0.
Juventus moved for points clear at the top of Serie A after a 3-0 victory at Empoli, while Napoli slipped up at Atalanta.
Three-time champions Inter Milan face a battle to get through Europa League Group K after a second successive defeat.
Juventus, who beat Cagliari 4-0, move to the top of Serie A after Napoli were held to a 0-0 draw at Genoa.
Mauro Icardi inspired a superb comeback win for Inter as they beat Juventus 2-1 on Sunday, while Roma lost at Fiorentina.
Chelsea have signed defender Marcos Alonso from Fiorentina.
Marcos Alonso is heading to London with the Fiorentina defender set to complete his move to Chelsea, according to Sky sources.
Chelsea are in advanced talks to sign Fiorentina left-back Marcos Alonso, according to Sky Sources.
Man Utd will face Fenerbahce, Feyenoord and Zorya Luhansk in the Europa League, while Southampton are in a group with Inter Milan.
Italy international Giuseppe Rossi has joined Celta Vigo from Fiorentina.
Gonzalo Higuain quickly showed his value by coming off the bench to score the winner in Juventus' 2-1 victory over Fiorentina on the opening day of Serie A.