Fiorentina put a dent in Juventus' title charge with a 2-1 win at the Stadio Artemio Franchi.
Serie A leaders Juventus returned from their winter break with a 3-0 dismantling of Bologna on Sunday night.
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Roma bounced back from their Serie A defeat to Juventus at the weekend by coming from behind to beat Chievo 3-1.
Radja Nainggolan punished AC Milan for missing a first-half penalty by firing Roma to a 1-0 Serie A victory on Monday.
Manchester United will face Saint-Etienne in the Europa League round of 32, while Spurs will take on Gent.
Dundalk's hopes of qualifying for the Europa League knockout stages were ended after a 2-1 defeat at Maccabi Tel-Aviv.
A rare goal from Kevin Strootman helped Roma reclaim second place in the Serie A table as they beat derby rivals Lazio 2-0 on Sunday.
Inter Milan held on to beat 10-man Fiorentina 4-2 and hand boss Stefano Pioli his first win since taking charge.
Inter Milan let a two-goal lead slip as they crashed out of the Europa League with a 3-2 defeat to Hapoel Be'er Sheva.
Roma lost further ground on Serie A leaders Juventus when they were sunk by a late penalty and lost 2-1 at Atalanta.
Juventus maintained their four-point lead at the top of the Serie A table after Miralem Pjanic struck a late winner at Chievo.
Aritz Aduriz netted five goals in Athletic Bilbao's 5-3 win over Genk in the Europa League on Thursday, as Ajax, Schalke, Shakhtar and Zenit all progressed.
Gonzalo Higuain's second-half winner saw Juventus clinch their 22nd consecutive home win in Serie A with a 2-1 victory over Napoli.
Joe Hart was at fault for Mauro Icardi's first goal as Inter Milan beat Torino 2-1 in Serie A on Wednesday.
Frank de Boer's future as Inter Milan head coach is under serious threat after a 2-1 defeat to Atalanta in Bergamo on Sunday.
Shakhtar Donetsk maintained their 100 per cent start to Europa League Group H as they thrashed Gent 5-0.
Juventus moved for points clear at the top of Serie A after a 3-0 victory at Empoli, while Napoli slipped up at Atalanta.
Three-time champions Inter Milan face a battle to get through Europa League Group K after a second successive defeat.