Last Updated: 29/06/14 12:58am
That's all from this minute-by-minute commentary - check back for a match report and reaction. Thanks for joining me.
Full-time at the Maracana: Colombia 2 (James Rodriguez 28, 50) Uruguay 0. Colombia will face Brazil in the second quarter-final in Fortaleza next Friday.
Third and final change of the night for Colombia - Adrian Ramos ON, James Rodriguez OFF. Standing ovation for the two-goal forward (85).
YELLOW CARD! Referee Kuipers has booked injured Uruguay captain Diego Lugano for his protestations from the bench. That was all to do with Ramirez's rather wild challenge on Armero on the touchline. The Colombian needs treatment, but he'll continue (77).
Colombia's possession count is down to 57% now as Uruguay get to see more of the ball. On shots, Tabarez's team lead 12 to nine - but Colombia have four on target to Uruguay's two.
Cristian Rodriguez tries to make it happen for Uruguay with a fierce shot from distance after driving through the midfield - but Ospina dives to his left to make the save.
Not only is James Rodriguez leading the race for the Golden Boot, his Colombia colleague Juan Cuadrado now has the most assists in the tournament, with four.
YELLOW CARD! Uruguay's teenage centre-back Jose Maria Gimenez is the first player booked by referee Bjorn Kuipers, for a late slide tackle on Teofilo Gutierrez (55).
Uruguay coach Tabarez is making changes, unsurprisingly. Stuani and Gaston Ramirez ON, Forlan and Alvaro Pereira OFF (53).
It's that man again! Gutierrez starts the move on the right before play is spread to Armero on the other flank. His deep cross is headed back and down by Cuadrado to the edge of the six-yard box where James Rodriguez is there to sweep home his fifth goal of the tournament. He's now the World Cup's leading goalscorer.
Remember, the winners of this game will face hosts Brazil in Fortaleza on Friday night in the second of the quarter-finals.
What did you make of the first half? Colombia have bossed possession (65% to 35%) and have had seven shots (three on target) to Uruguay's four (none on target).
Half-time at the Maracana: Colombia 1 Uruguay 0. James Rodriguez's outstanding 28th-minute volley separates the teams in Rio de Janeiro.
Armero clears the ball on the edge of Colombia's box after good build-up play from Uruguay involving Forlan.
Ospina is called upon to make a diving save forwards as Gonzalez's shot takes a slight nick on its way towards him.
Referee Kuipers has to have a word with Yepes and Forlan who have had a heated argument in the penalty area.
Cavani goes close with a free-kick attempt from almost 30 yards out, but the ball dips and swerves just over the bar. Uruguay better since falling behind.
A stunning goal from James Rodriguez, who takes Aguilar's pass on his chest 22 yards out and volleys a shot left-footed over the fingertips of Muslera, then sees the ball bounce down in off the bar! Stunning - a goal-of-the-tournament contender.
Cuadrado and Zuniga continue to be the lively performers for Colombia but they're not doing much to really threaten Uruguay.
Half a chance for Cavani as he races onto a long ball in the box but he can't keep the ball in play.
Colombia have had a whopping 71% possession in the opening 17 minutes of this game. But can they break Uruguay down?
Zuniga is on the floor once again after a rugged Uruguay challenge. He's had an outstanding start to the game.
Ambitious effort from Forlan as Yepes put pressure on him 25 yards out, the ball sailing high and wide.
Muslera has to make a save low down to his left as Zuniga races forward from the halfway line and strikes a shot from distance.
Some silky step-overs from Cuadrado who is brought down by a combination of Arevalo Rios and Alvaro Pereira.
Uruguay are indeed going for three at the back, with the Pereiras - Maxi and Alvaro - bombing down the right and left flanks respectively.
On email, Keith O'Connor is bucking the trend: 'I think Uruguay may surprise everyone tonight. They have a point to prove against FIFA - and the best way to do it is by lifting the trophy or at the very least, getting to the final. I reckon 3-2 to Uruguay in extra-time.'
Here's some Sky Bet Price Boosts for you. Colombia's Juan Cuadrado to score the first goal is now 12/1; a 2-0 Colombia win in normal time is 9/1; and a 2-1 Uruguay victory within 90 minutes is a tempting 16/1.
Also on email, Chris Green predicts who will be setting up a clash with Brazil next Friday night: 'Colombia to win 2-1.'
Jordan Green on email is looking forward to this one: 'Let's see how Uruguay do without Suarez. They were poor against England - only two shots on target, and Suarez scored the two.'
Let's look at the betting. Colombia are 11/10 favourites to win this one within normal time, while you can get 14/5 on Uruguay. The draw at 90 minutes is 23/10.
Colombia and Uruguay's only previous World Cup encounter was in the group stages of the 1962 tournament. The Celeste won 2-1, despite Colombia opening the scoring. It is Colombia's only previous game against a fellow South American team at the World Cup.
Our man Charlie Nicholas has had a look at this game and is going for a 3-1 win to Colombia: 'Without Suarez, I don't really see how Uruguay are going to a stop a quick and rugged Colombia team in this game.'
It'd be great to hear your feedback on this one. You can get in touch with me throughout the evening by emailing email@example.com or tweet me at @jonboy79.
So Oscar Tabarez selects Diego Forlan to replace the banned Luis Suarez in attack. Nicolas Lodeiro also drops out of the side that began the 1-0 Group D win over Italy, with Maxi Pereira returning at right wing-back.
Uruguay starting line-up (3-4-2-1): Muslera; Gimenez, Godin (c), Caceres; M Pereira, Arevalo Rios, Gonzalez, A Pereira; Forlan, C Rodriguez; Cavani.
A slight surprise there from Colombia coach Jose Pekerman, who selects Jackson Martinez ahead of Victor Ibarbo. Those two goals against Japan last time out have made a big impression. He's made seven changes in total from that game.
Colombia starting line-up (4-2-3-1): Ospina; Zuniga, Zapata, Yepes, Armero; Aguilar, Sanchez; Cuadrado, Rodriguez, Martinez; Gutierrez.
The two teams now know they are battling for the right to face hosts Brazil in the second quarter-final in Fortaleza next Friday. That's after Luis Felipe Scolari's side thrillingly beat Chile 3-2 on penalties after a 1-1 draw.