Last Updated: 27/11/13 9:41pm
The final whistle goes and United can celebrate a wonderful European night, having sealed their place in the Champions League last 16 with a 5-0 demolition of Bayer Leverkusen.
Kohr is shown a yellow card for dissent after a foul in midfield, as three minutes of stoppage-time are signalled.
GOAL! Nani adds a fifth for United. Giggs guides a good pass forward but the Portuguese still has a lot of work to do as he expertly controls the ball and races past the onrushing Leno. It looks like the ball will beat him to the byline but he catches up and exquisitely flicks it back with the outside of his right boot from a tight angle to send it spinning into the goal.
United are really enjoying themselves with a lot of possession as the clock ticks down, while the final whistle cannot come soon enough for Leverkusen.
Anderson nearly makes an immediate impact with a fifth for United as he is presented with a chance to score after another flowing move, but in the end it is bad miss as he scuffs wide from the edge of the area.
Rooney makes way for the closing stages, along with Valencia as Young and Anderson are brought on by Moyes.
Jones tries to get in on the act with an ambitious volley from a corner which he does not connect with cleanly, and Leno makes a routine save down to his left.
GOAL! Smalling adds more gloss to the scoreline with a fourth United goal. Kagawa picks out Rooney with a sublime chipped pass and the England striker lifts an unselfish pass over the onrushing Leno for Smalling to put the ball in from close range.
It has been a very well-rounded performance so far from United, as they look solid defensively and threatening in attack, with Rooney and Kagawa particularly sharp and Nani and Valencia also lively.
Castro delivers a decent free-kick following a foul by Buttner, but Bender's looping header fails to trouble De Gea as it lands on the roof of the net.
Kiessling shows good determination to try and shake off a couple of defenders in the United box and haul Leverkusen back into the game, but the door is shut in his face in the end by a strong Smalling tackle.
Leverkusen respond with a double change of their own, as Hegeler and Derdiyok replaces Reinartz and Son.
United do not look like they are finished yet as Rooney and Kagawa combine nicely once again. The two of them have really had a good understanding in attack tonight.
GOAL! Evans Puts United 3-0 ahead. Evra wins the initial header from a corner and Rooney forces Leno into a save with a shot which lacks power. Evans seizes on the loose ball and keeps it out of Leno's grasp before turning it in from point-blank range.
Valencia has so much space down the right-hand side as he latches on to a clever Kagawa pass and dinks in a cross which is headed away for a corner by Toprak.
Rooney has made two goals and now wants one himself, as he curls a nice-looking strike narrowly wide of Leon's right-hand post from 25 yards.
Valencia shrugs off Can down the right wing and cuts inside, but Leverkusen have numbers back and his cross is blocked.
Leverkusen almost grab a lifeline from a corner as Reinartz's near-post header takes a couple of ricochets and hits the bottom of the post. The rebound falls to Spahic but he is unable to squeeze it in from a tight angle with United defending desperately.
A stray Spahic pass inside his own half is intercepted and Rooney feeds the ball on to Nani, but he drills a shot wide from the edge of the box.
Valencia has had the better of his opposing full-back so far tonight, but on this occasion Can just gets a vital touch on the ball to disrupt his run.
Kiessling has been a peripheral figure apart from that one good run in the first half, and he is unable to get on the end of a poor right-wing cross from Donati that flies over his head.
Giggs gives away a free-kick for a foul on Bender as he tries to keep Leverkusen pinned back in their own territory.
Leverkusen apply a bit of pressure as they win a free-kick after some decent possession, and United's defence looks all at sea for once tonight as they struggle to deal with the set-piece.
Valencia floats over a cross from the right and Leno clatters into Kagawa as he goes to punch the ball away before it can be headed in. The Japanese star gets there first but is only able to direct his effort wide and stays down momentarily after taking such a hefty knock, before returning gingerly to his feet.
United look dangerous every time they break and it is Rooney pulling the strings on the latest counter-attack, but Kagawa is just unable to control his final pass into the centre and Leno rushes off his line to gather the ball.
It doesn't look like United have any plans to sit back as they start off as they finished the first half, on the front foot.
Manchester United get the second half started. There have been no changes at the break but Hyypia surely won't leave it long before freshening up his attack.
The whistle goes for half-time and United are in complete control at 2-0, thanks to a close-range Valencia strike and a Spahic own goal. If they can protect their lead after the interval they will guarantee a place in the knockout rounds.
Smalling sends in a menacing low cross after an overlapping run down the right. Toprak gets it clear but only as far as Valencia, whose drilled delivery is well held by a diving Leno.
Leverkusen win another corner but once again they fail to make the most of it as a firm header clear sets Nani on the counter-attack. However, he lacks support and the danger fizzles out.
Son appeals for a high boot from Ferdinand after being dispossessed by the United defender, but the referee gestures that the South Korean had stooped low.
Leverkusen win a corner following some good play by Bender, but Castro's delivery curls out before it curls back in again and the chance goes to waste.
Leverkusen are having to try and push forward more now and Rooney is caught offside as United try to take advantage of the home side's higher line.
Leverkusen weather the storm with a spell of possession, but their final ball has not been good enough yet and it is Smalling who heads powerfully clear on this occasion.
Kagawa darts away from a couple of defenders though the centre and has the option to pass out wide to either side, but he opts to take it on himself and drags a disappointing low shot straight at Leno.
United have one foot firmly in the last 16 now as they come forward again, looking to put this match to bed before half-time.
GOAL! United make it 2-0 thanks to a Spahic own goal. Rooney delivers a stunning free-kick from wide on the left and the Leverkusen defender, rising for an aerial challenge with Smalling, inadvertently flicks a header past his own keeper and into the top corner.
Kagawa really made his reputation in Germany as a star for Borussia Dortmund, and he is enjoying his return to the country tonight with some really good touches.
The BayArena faithful are trying to rally their side but it is the travelling fans in great voice just at the moment, with United looking full of confidence.
United come close to a second as the Leverkusen defence is torn apart once again, but Jones' shot from the edge of the area is blocked.
GOAL! Valencia makes it 1-0 to United. It is a well-worked and quick move from the visitors as Kagawa bursts forward in midfield and finds Giggs, who plays it wide to Rooney. The England striker dinks a delightful ball beyond a couple of defenders to the back post, where Valencia keeps his composure to provide a finish from close range.
Evans comes to United's rescue with a superb last-ditch tackle to deny Kiessling from close range after the Leverkusen forward had wriggled past a couple of challenges and just let off a shot.
Castro just fails to beat the offside trap as he tries to latch on to a Rolfes pass, and blazes his shot high and wide anyway without realising the whistle had gone.
Leverkusen look a threat from set-pieces and Spahic wins the header from the corner, but his glancing effort drops on top of the goal.
Son is drifting into some good positions for Leverkusen and he lets off another low shot from 20 yards, which is deflected wide for a corner.
Nani shows his speed to set up a United attack and the ball is worked over to Smalling on the right, but his low cross is poor and fails to beat the first man.
Giggs picks out Nani after some great link-up play also involving Evans and Evra, but the Portuguese's curling shot from the edge of the area is just over the top of Leno's goal.
Evra surges down the left wing after winning the ball and his attempted pass towards Kagawa strikes the arm of Donati, giving United a free-kick in midfield.
Ferdinand heads clear a left-wing cross from Rolfes but Can swings the ball back in and De Gea has to back-pedal to take the high catch, remaining careful that he does not step over his line.
Spahic aims a long ball through the middle in an attempt to release Kiessling, but the pass is too heavy and it causes no problems for United.
Leverkusen have settled into a solid defensive shape, sitting back quite deep and allowing United to keep possession.
Leverkusen break quickly through Kiessling but Smalling is alert to the danger and steps in with a no-nonsense clearance.
Valencia threatens with a strong run down the right as United pin Leverkusen back in their own half.
Goalkeeper Leno boots a nervy kick straight out of play as United apply some good pressure and see plenty of the ball.
It is shaping up to be an open game, with both sides showing plenty of attacking intent in the early stages.
Son picks up the ball in midfield for Leverkusen and drives forward before trying his luck with a shot from 25 yards, but his low effort skims harmlessly wide.
United quickly find some fluency with a neat move which nearly results in an early Rooney chance, but the flag is up for offside.
Leverkusen get the game started. United's players are wearing black armbands this evening in memory of former defender Bill Foulkes, who dies earlier in the week at the age of 81.
The Champions League anthem booms around the ground as the players emerge from the tunnel, with former United boss Sir Alex Ferguson seen taking his place in the stands.
Tyler from Kettering says: "Really encouraged by the team selection, going to Germany and attacking. It will be interesting to see how Nani plays in the middle. Just glad to see Cleverley not playing, not enough effort and not good enough for Man United. Going for a Man Utd win, 2-0 Rooney both. COME ON YOU REDS!!!"
United are sure to be wary against a Leverkusen side looking to clinch qualification themselves with a home win. The German side, coached by former Liverpool defender Sami Hyypia, are currently second in the Bundesliga, three points ahead of Borussia Dortmund, and their draw with Bayern Munich last month remains the only time they have failed to win at the BayArena this season.
Chris Green from Huddersfield says: "I expect United to have no problems here and seal qualification with ease, but if they allow the Germans to have any easy chances, a shock could be on the agenda this evening."
George from Canada writes: "Nani, Kagawa, Giggs and Jones will make the big difference today. I predict a Manchester United victory - 2 to 1."
United may not yet have convinced all their fans, such as Adrian, but they have found some consistency over the past few weeks. Although they were held to a 2-2 draw by Cardiff City on Sunday, the Red Devils have now gone ten games unbeaten in all competitions to move to the brink of qualifying for the Champions League knockout stages and stay in contention for the Premier League title.
This just in from our friends at Sky Bet: Manchester United have drifted from 15/8 to 21/10 to secure the victory tonight following the news that Van Persie and Vidic miss out, with Bayer Leverkusen 7/5 favourites to win and the draw 23/10. However, United are still odds-on to win Group A with their hosts 5/2 followed by Shakhtar Donetsk at 9/1. Wayne Rooney is the 11/2 favourite to score first with Nani Price Boosted to 16/1.
Adrian from Bristol is the first to get in touch, saying: "I have watched my boys every week , and we just are not playing well. We seem to show promise and that's it. We are definitely missing Fergie, and the backroom staff. Tonight I feel we will be lucky to come home with a draw , really disappointed with them so far."
Bayer Leverkusen: Leno, Donati, Spahic, Toprak, Can, Bender, Reinartz, Rolfes, Castro, Kiessling, Son. Subs: Lomb, Stafylidis, Wollscheid, Derdiyok, Hegeler, Kruse, Kohr.
Man Utd: De Gea, Smalling, Ferdinand, Evans, Evra, Giggs, Jones, Valencia, Nani, Kagawa, Rooney. Subs: Lindegaard, Anderson, Hernandez, Young, Welbeck, Cleverley, Buttner.
Manchester United are currently top of Group A and will book their spot in the last 16 with a victory this evening. They can also go through with a draw if Shakhtar Donetsk are beaten by Real Sociedad in the night's other match, and such a scenario would also send Leverkusen into the knockout stages. Leverkusen are second in the standings at the moment and if they win they will seal a place in the next round, leaving United to sweat ahead of their final game at home to Shakhtar.
Let us know your views and predictions ahead of the game by getting in touch Lewis.Rutledge@bskyb.com, or via Twitter @SkySportsLewis. Will United finish the job tonight and reach the knockout stages, or will Leverkusen come out on top on home soil? The full team news will be in shorty but who do you think are likely to be the key players?