Last Updated: 17/09/13 9:43pm
The full-time whistle goes and Man Utd have beaten Bayer Leverkusen 4-2 to get off to a winning start in Group A and give David Moyes a perfect debut in the competition. Rooney was the star as he scored twice to bring up 200 goals for the club.
Terrible miss! It is too late to really matter but Van Persie has just outdone Rooney with a shocking miss. Valencia fired in another fierce cross from the right and Van Persie made contact just a couple of yards away from an open goal, but somehow managed to turn it wide.
GOAL! Toprak reduces Leverkusen's arrears late on as De Gea flaps at a corner and is unable to prevent Reinartz from crashing a header against the crossbar. Toprak reacts quickest from the rebound to poke the ball home.
Leverkusen enjoy a rare foray into United territory before Boenisch's cross is intercepted by a Ferdinand header.
The Man Utd fans rise to applaud Rooney following a wonderful performance as he goes off to be replaced by Hernandez.
It is all one-way traffic now as United begin to enjoy themselves with some sparkling passing exchanges.
Another change for Man Utd as Cleverley replaces the impressive Fellaini for the closing ten minutes.
GOAL! Man Utd extend their lead to 4-1 with a fabulous breakaway goal from Valencia. Young leads a sweeping counter-attack down the left before playing in Rooney through the centre. Rooney provides the killer pass through to Valencia and he smashes a low shot past Leno from the edge of the area.
Valencia again goes for power rather than precision as he drives in a cross from the right which lacks the finesse to unsettle Bayer's back line.
Leverkusen get a free-kick 25 yards from goal but Sam's curling effort lacks the power to trouble De Gea and it is a comfortable save.
Kiessling had been identified as one of the major threats tonight but he has been starved of service and has really struggled to impose himself on the game.
Man Utd have been helped by some poor defending from Leverkusen, and some good luck for the first goal, but it has been a decent performance overall and Moyes will be delighted if they finish the job tonight. Meanwhile, Young has come on for Kagawa.
GOAL! De Gea launches a long ball forward which Leverkusen are unable to deal with and it falls for Rooney to run through on goal. He missed a great chance earlier but there is no mistake here as he coolly lifts his shot over the onrushing Leno and in at the near post to give United a cushion at 3-1. It is also a landmark moment for Rooney as it brings up 200 goals for Man Utd.
Valencia is released down the right following good play by Van Persie and Rooney, but his shot from the edge of the area is deflected wide by the heel of Boenisch.
Rooney steps up to take the free-kick but his powerful strike crashes into Can on the end of the defensive wall.
Donati's mistimed challenge on Van Persie gives United a free-kick in a central position just a few yards outside the area.
Hamburg make their first change of the night as Son is replaced by Bender, who is a key player for the Bundesliga side and only started among the substitutes because of recent injury problems.
Sam drills a cross-field pass out to Boenisch, who plays a one-two with Sam before blazing a wild shot high into the stands.
It is a really open game now and we are set up for a thrilling climax as Leverkusen try to rally and equalise for a second time.
GOAL! Valencia delivers a fine cross from the right wing and Van Persie acrobatically hooks a volley towards goal with his right foot. It is well struck but is more or less straight at Leno, and the Leverkusen keeper is left hanging his head in shame as he tries to punch it clear but fails.
United win a corner but it comes to nothing as they are frustrated in their attempts to quickly restore their lead.
The Old Trafford faithful are stunned into silence and it is the traveling support who are making all the noise as Leverkusen come forward again, with Sam blazing an ambitious shot high and wide from 25 yards.
GOAL! Man Utd are made to rue that miss as Rolfes tries his luck from 20 yards and his shot takes a wicked deflection off Carrick to fly into the corner of the goal and leave De Gea no chance.
What a miss! It is a comedy of errors as Toprak slips on the edge of his area to present Rooney with a glorious chance. He does the first part well as he skips round Leno, but then fires horribly across goal and wide on the other side with his left foot. He had been taken out to a narrow angle, admittedly, but it is still a bad miss and he even had the option to wait for Van Persie and play him in.
Ferdinand fails to clear a high ball into the United box and Sam is as quick as a flash to get hold of the ball and let off a powerful snap-shot on the turn, but it is straight at De Gea.
Van Persie concedes a free-kick for blocking off Rolfes. Having already been booked in the first half, the Dutchman will have to be careful.
With no obvious option, Valencia drives in a ferocious cross which crashes into the back of Van Persie and drops behind for a Leverkusen goal-kick.
It has been quite a gentle tempo at times and United again look in no rush as they pass it around patiently in midfield.
Rooney tries to find Van Persie with a cross from the left but it is too close to Leno and he makes a routine stop.
United finish the half with a brief spell of intense pressure as Van Persie drags a shot narrowly wide. Leverkusen will let out a sigh of relief at reaching the interval as they get a chance to regroup without suffering further damage, but they will also feel incredibly frustrated to be trailing 1-0 as there was an argument that Rooney's goal should have been disallowed.
Kagawa brings down a diagonal Valencia cross beautifully on his chest and shoots for goal, but it takes the slightest of deflections of Cam and flies wide of the post.
Man Utd win a free-kick just outside the area and Rooney steps up to curl a sumptuous free-kick past the defensive wall. Leno dives full-length to his right but is not required in the end as the ball whistles inches outside the post.
Smalling's attempted low cross from the right is intercepted by Donati as a promising Man Utd attack is halted abruptly.
Van Persie becomes the first United player into the book as he barges into Donati and then shows his dissent to referee Skomina.
Kagawa plays in Van Persie with a fine pass and the Dutchman elects to cut it back again rather than try to take on the advancing Leno, but it is behind Rooney and Rolfes gets there before Valencia to clear.
Rolfes wins the ball for Leverkusen and a series of slick one-touch passes helps them carve open United, but the final ball is poor and United survive.
Fellaini has done a lot of good work in front of the back four this evening and again heads powerfully clear to give United some breathing space.
Boenisch is getting forward well from left-back, while Donati also shows that he can contribute in attack with a shot from distance that is deflected wide.
United are still dominating in terms of possession but Leverkusen are just starting to look a bit more menacing as they win a couple of corners in quick succession.
De Gea has had an easy night so far but he is unconvincing here as he comes out to try and claim a corner and gets nowhere near the ball. Luckily for United, it flies through an area where no Leverkusen players are lurking.
Rooney is in fine form tonight, as he skilfully brings down a long pass and then turns inside Spahic before just letting the ball run out of play and over the byline.
Leverkusen respond strongly as Sam makes his presence felt in attack, but Evra coolly shepherds the ball back to De Gea.
Leverkusen were unhappy that the goal stood as they felt Valencia was impeding Leno on the line as the ball flew past him. Replays show they had a case, and perhaps that should have been given as a foul. Valencia was definitely offside anyway, while Evra may have also been offside before he crossed, so Leverkusen can certainly feel aggrieved.
GOAL! Rooney puts Man Utd 1-0 in front with a bit of a scuffed volley from Evra's left-wing cross which bounces on its way past Leno from 12 yards.
Van Persie whips in an inswinging free-kick and the ball loops up off Smalling's head. Leno had come off his line and looks back anxiously, but it has dropped over the crossbar.
Reinartz is booked following a late challenge on Carrick, giving Man Utd a free-kick in a decent area.
Carrick tries to pick out Fellaini at the back post with an ambitious long pass but it is just too close to Leno and the Bayer keeper safely plucks the ball out of the air.
Valencia digs out a cross from the right wing but it is poorly directed and goes behind his team-mates in the centre, allowing Sam to clear for Leverkusen.
Rooney sprints away from Son and the Leverkusen player has to resort to a foul to stop him in his tracks, earning himself a booking in the process.
Reinartz's long-range shot strikes Vidic on the body, maybe even the arm, and there are a couple of half-hearted appeals for a penalty as the ball deflects behind, but there was clearly no intent there.
Leverkusen win a corner but Sam's delivery is poor and, when the ball eventually comes back into the centre, it is emphatically cleared by a powerful Fellaini header.
Fellaini finds Van Persie with a neat first-time pass and the Dutchman takes advantage of that extra split-second to fire off a low shot which has Leno scrambling but skids wide of his left-hand post from 20 yards.
Reinartz concedes a free-kick for a late tackle on Fellaini, as the challenges fly in and both sides battle for supremacy in midfield.
Rooney tries his luck with a shot from 20 yards after being fed by Kagawa but Spahic is out quickly to make a solid bock.
Valencia tries to use his pace to burst away down the right wing but Boenisch is equal to the task and shows good strength to win back the ball.
Rooney, again wearing that black protective headband which makes him look like a contestant on Gladiators, drifts out to the left to support Evra in a threatening attack.
Smalling is spoken to by the referee following a clumsy challenge on Reinartz, but there is no card on this occasion from Slovenian referee Damir Skomina.
The early impression of Leverkusen, who are lining up in a 4-3-3 formation, is that they are well organised and will be hard to break down. The German side appear prepared to sit back and let United have the majority of the ball, and will then look to attack quickly on the break.
Fellaini and Kagawa, two players who will be particularly eager to impress tonight, combine nicely in the centre of the field as United probe patiently.
Smalling battles his way out of a corner inside the opening moments before United enjoy a spell of possession in midfield which will help settle any early nerves.
Bayer Leverkusen kick us off at Old Trafford and let us hope for an exciting encounter to mark the start of another year in the Champions League.
Anthony from Dubai writes: "United will defeat Leverkusen today. I reckon a 3 - 1 scoreline in favour of United."
Naeem Crouchy says: "Great to see Moyes finally starting Kagawa! He's a great player and I reckon he'll play a big part in helping United win today. We've got a strong team, my prediction: 3-0 ."
The two other teams in Group A are Real Sociedad and Shakhtar Donetsk, who meet in Spain tonight. It is a tough group as all four teams will fancy their chances of making it through to the knockout rounds, but United will be regarded as the side to beat and, as always in Europe, it is vital they pick up the majority of their points at home.
Justin Lazenby, working the graveyard shift in Brisbane, says: "I'm thinking 2-0 Utd with Rooney and RVP to get the goals again!!"
"I don't think anyone will deny that the Bundesliga is currently proving to be a better league than the premier league. However, Leverkusen were very much the bridesmaids to Bayern and Dortmund last season, whilst Utd won the premier league in a canter. A home win banker for me 2-0. Nick Garbett in Birmingham."
Managed by former Liverpool favourite Sami Hyypia, Bayer Leverkusen are sure to pose a serious test to United tonight. Bayer finished third in last season's Bundesliga, behind Champions League finalists Bayern Munich and Borussia Dortmund, and have an opportunity to further demonstrate the strength of German football. Leverkusen will also be in confident mood after starting the new domestic season with four wins out of five, most recently a 3-1 victory at home to Wolfsburg on Saturday.
Stuart Cameron says: "United's midfield looks very strong with a mix of defence and attack, I'm actually genuinely excited to see how it goes. I think they're still missing Rafaels runs though."
Whilst we wait for kick-off why not visit our friend at Sky Bet for a pre-match flutter, with Man Utd at 5/6 for the win and Bayer 19/5.
Well Ben, your wish has come true as Moyes hands Marouane Fellaini his first Manchester United start and selects Shinji Kagawa in the starting XI for the first time this season. Defender Chris Smalling is also included as Moyes makes three changes to line-up from Saturday's win over Crystal Palace.
Ben writes: "Can see man you getting off to a good start with a 3-0 win & Rooney to be the key man. Hope he plays Kagawa & Fellaini."
United have started the new season in solid rather than spectacular form. They were impressive in demolishing Swansea 4-1 away from home, but were then held to a dour 0-0 draw by Chelsea and lost 1-0 to Liverpool, before overcoming ten-man Crystal Palace 2-0 at the weekend to keep very much in touch with the early Premier League leaders.
Man Utd: De Gea, Smalling, Ferdinand, Vidic, Evra, Valencia, Carrick, Fellaini, Kagawa, Rooney, van Persie. Subs: Lindegaard, Evans, Anderson, Hernandez, Young, Fabio Da Silva, Cleverley.
Bayer Leverkusen: Leno, Donati, Spahic, Toprak, Boenisch, Can, Reinartz, Rolfes, Sam, Kiessling, Son. Subs: Palop, Wollscheid, Bender, Derdiyok, Hilbert, Oztunali, Kruse.
Gabriel is the first to get in touch, saying: "I reckon Leverkusen might come away with a draw here. Lars Bender being fit is a big plus for Sami Hyypia's side, and they can be strong on the counter attack. Moyes might want to rest two or three experienced players ahead of the big game on Sunday, and there's a lot of pressure on him for this game, so a 1-1 draw feels about right."
United go into this year's Champions League among the favourites to go all the way but they have bad memories of last season's competition after an agonising loss to Real Madrid in the last 16, when Nani was controversially sent off in the second leg. Having reclaimed their Premier League title in style, the Red Devils will now be determined to make an impression in Europe.
Let us know your views and predictions by getting in touch at Lewis.Rutledge@bskyb.com, or via Twitter @SkySportsLewis. Will Man Utd and Moyes make a winning start to their Champions League campaign or can Leverkusen spring a surprise? The full team news will be in shortly but who do you think are likely to be the key players?
Good evening and welcome to our minute-by-minute commentary of Manchester United's UEFA Champions League game against Bayer Leverkusen. It is the first European night at Old Trafford since Sir Alex Ferguson stepped down as manager at the end of last season and a special occasion for David Moyes as he makes his debut in the group phase of the competition.