Last Updated: 25/03/14 9:48pm
That's all from this live commentary for tonight. Thanks for joining me. Check the site for a full report and then match reaction.
Full-time: Manchester United 0 Manchester City 3 (Dzeko 1, 56, Yaya Toure 90). City are up to second in the table, three points behind leaders Chelsea with two games in hand.
Fernandinho is Gary Neville's pick as Man of the Match tonight. The Brazilian has knitted things together superbly for City in midfield.
Milner's cross from the right deflects off the heels of Jones, right into the path of Toure at the top of the box. The Ivorian takes one touch before snaking a powerful low shot to the right of De Gea. Three minutes of added time to follow.
Kompany lunges for the ball ahead of Hernandez and manages to connect, but Oliver blows his whistle. The City skipper - already booked - briefly thinks he's about to be shown a red card.
Rooney is frustrated after his shot hits Clichy. City build another counter-attack and when Valencia pushes Zabaleta in the box, the away fans appeal for a penalty - but it's not given.
Rooney tries his luck with a powerful free-kick from out on the left but Hart dives with his left hand and punches the ball clear.
City's second change - Milner ON, Nasri OFF. Impressive showing from the France international tonight.
Hart has to make a sharp reaction save after Demichelis left Welbeck in the box. The England man span and backheeled a shot from close range, but Hart was equal to it.
Welbeck comes back onto his right foot after being fed into the left side of the area by Rooney, but his tame low shot is held by Hart.
Fernandinho is set up for a shot in the centre by Toure's perfectly weighted pass from the left, but he leans back and fires over.
A brief scare for Ferdinand, who has to readjust his feet in the six-yard box to clear Navas' ball in from the right out for a corner.
Dzeko's inclusion ahead of Negredo surprised many of you, but he's justified his inclusion tonight. Nasri has also claimed two assists (of a fashion - the first came when his shot hit the post).
Dzeko makes a run to the near post with Ferdinand languishing in his wake and connects superbly to divert Nasri's corner inside the post for his 10th league goal of the season.
More magic from Silva before slipping in Dzeko on the left side of the box. Jones tackles to force a corner, then heads behind for a follow-up set-piece...
Demichelis intercepts Rooney's low ball in from the right. Then Hart scoops up another cross from the same United player.
... and Fernandinho almost profits from it! The ball comes at his head at pace in the six-yard area after Kompany's near-post flick-on, and the Brazilian can only direct it over the bar.
City win another corner as Evra blocks off Navas on the right byline. This is the visitors' fifth, United have had four...
De Gea is walking rather gingerly, looks like he's turned his ankle. Should be OK to continue though.
Dzeko get a sight of goal at the start of the second half too, but his effort is blocked. Then Carrick slides in on Zabaleta to force a corner.
Via Twitter, Paul Owen (aka @blacktaxipaul) says: 'Shocking defending by United. Why hasn't the ref sent Fellaini off for a deliberate elbow? United so slow - let's see if they draw.' Meanwhile, @NiallPDoolan adds: 'City started off fantastically, but gradually United got back into it. United need a goal and early before City score again.'
On email, we have Tyrell Goncalves' thoughts: 'Unfortunate start for United but I have to admit Cleverley is doing the job in midfield, he always lights up in the derbies, but they have to stay tight on Silva, because he's been causing problems. Anyway, I think put a good showing towards the end, bring on Kagawa for that creativity.'
Here's how the betting has changed. United are now 7/1 to win this derby, with City 1/3 to come out on top. The draw is priced up at 100/30 by Sky Bet.
Lauren Gallagher writes: 'Slow start by United, however they soon got back into the game. This season, they've struggled when they're behind. As always, De Gea came to our rescue and I'm really enjoying seeing the growing partnership between Mata and Rooney. Also, got to give Welbeck & Rafael a mention as I think they've been on form tonight.'
Half-time: Manchester United 0 Manchester City 1 (Dzeko 1). Awful United defending for the opener after just 43 seconds, tucked home from close range after Nasri's shot hit the post. City could have had more in the early stages, but then United gradually came back into the game. Fellaini fortunate to not be red carded for a fairly obvious elbow on Zabaleta.
Evra climbs all over Zabaleta on the set piece and it's a United free-kick. Three minutes of added time.
The possession count almost balanced out now - United have raised their game and have got up to 47%. They also win another corner, making it 4-3 on those.
Clichy tracks the run of Fellaini and manages to nod a left-wing cross out for a corner ahead of the Belgian.
Cleverley feeds Rafael on the right, and his low cross misses Rooney before finding the feet of Mata - only for the Spaniard to blaze his shot over the bar. Arguably United's best first-half opening.
Evra delivers the ball in for Welbeck. However, Hart times his leap well and plucks it off the United striker's head.
Nasri tries to thread the ball through for Dzeko in the box but Phil Jones blocks off the City attack.
YELLOW CARD! Fellaini, who was on the ball, leads with his elbow into Zabaleta, for no obvious reason. The United midfielder is lucky not to be sent off for that.
United nearly open City up straight down the middle, more by luck than design admittedly as Fellaini tried to bulldoze his way through.
Fellaini's shot is saved by Hart. Carrick crossed into the area and Welbeck chested the ball left to the Belgian, but his effort lacked real power.
Midway through the first half, and an element of calm has briefly descended on proceedings. City have had 61% possession so far.
United win their second corner of the game. Joe Hart chooses to punch Rooney's delivery straight up in the air, strangely.
Silva passes into the box from the right looking for Nasri. United cope, then Welbeck receives the ball on the left side of the City area but Kompany blocks him off.
United in peril at the back once more as De Gea is forced to dive to his left to save from Dzeko. Then on the counter-attack, Kompany has to clear Mata's left-wing cross which was heading for Welbeck. End to end!
YELLOW CARD! Welbeck over-runs the ball and as Zabaleta clears, the United striker launches himself into a full-blooded attempt to block. Both players are down injured. Welbeck is cautioned.
The United defence has been living dangerously, to say the least. Again City go close, with Rafael's interception almost putting United back in trouble.
Huge chance for Silva, who strode into the penalty area and bore down on De Gea but saw his effort blocked. The ball didn't reach the lurking Yaya Toure either. Frenetic opening, this.
That goal for Dzeko made it six in eight games for the Bosnian against United, covering his time at Wolfsburg and City.
City win two quick corners, taken by Nasri. The second is cleared initially, but the ball comes back out to Yaya Toure who fires way over.
What a start! Only 43 seconds on the clock. Rafael makes a great block to stop David Silva who had slipped into the penalty area, but the ball is quickly played to the left side of the box by Fernandinho for Nasri. The Frenchman's shot hits a post and Dzeko sweeps home the loose ball from close range.
Michael J has emailed in with some tactical thoughts: 'I know a lot of people are slating Moyes for selecting Cleverley, but during last season's 3-2 win, I do remember him doing a good job man-marking Toure. Guessing Fellaini will operate more in the box-to-box role, while Mata will be allowed to wander. Their shape suggests that they want to clog midfield, which means Evra and Rafael will need to be at their best. Can't say I'm too optimistic about this game, hoping the Red Devils carry on their decent form of late and pull off an upset.'
The players have emerged from the Old Trafford dressing rooms and will be out on the pitch shortly. Evra and Kompany are preparing to lead out the teams. Michael Oliver is your referee this evening,
Edin Dzeko starts for City tonight. He says: 'We are ready, that's important! Derbies are always the biggest games of the season. Even if United are not in their best form, it's still a massive game for both clubs and the fans.' When asked if City will try to make a statement, the Bosnian added: 'That's not important, we must just try to win the game.'
How about a Sky Bet Price Boost? To score first, Juan Mata is now 12/1 and Yaya Toure is 8/1. Also available at 12s are a 2-1 United home win, and a 2-0 City victory. Or if you want to follow Jamie Redknapp's Hot Tips, City to win and both teams to score is a 5/2 shot.
Over to Lauren Gallagher on email: 'As a United fan, it's very strange to hear Liverpool and Chelsea fans cheering us on. Also I'd have liked to see Hernandez in the line-up. He worked his socks off against West GHam and I feel his talent is rotting away on the bench.'
Here's some of the thoughts of City manager Manuel Pellegrini before kick-off: 'We have more points than United but I don't think we are favourites. They are not in their best season but are still a big team with top players. We hope we can play as well as we did in the game at the Etihad.'
City have scored 3.2 goals per game in the 17 Premier League matches that Sergio Aguero has played in this season, compared to an average of 2.0 without the Argentina international. Will he be missed tonight?
Paul Scholes hasn't been impressed by Marouane Fellaini: 'He's not been great so far. I would have expected a lot more goals, for the amount of money United paid for him.' As for Juan Mata, Scholes adds: 'He's a classic number 10. He's not really hit the ground running and again, for the money, you want goals. But in his defence, he's been played out of position quite a bit.'
Simon Elliott on email writes: 'Who scores first is key tonight. If City score first, they will win 4-0, whereas if United score first, it will be 4-1!' A bold prediction that. Ryan Bishop says: 'City to win 3-1. United have obviously been dreadful this season and I think this is going to top it all off. RvP is a big miss but I think Rooney will score. Nasri, Kompany and Negredo for City.'
Here's the thoughts of United schemer Juan Mata pre kick-off: 'It's my first derby so it's very exciting. City are having a great season but we will try to win here, in our home. It's a pleasure to play behind Wayne. I have lots of good friends in the City squad, but today they are rivals as well as friends!'
Time for some SkyBet derby night odds. United are priced at 12/5 to claim victory tonight, while you can back City for all three points at 11/10. Clearly it's tough to call. The draw is 13/5.
On Twitter, Andrew McCarthy - aka @andyjmcca - is not impressed by Moyes' selection: 'I was quite optimistic about United's chances tonight. That was until I saw Cleverley's name on the team sheet. City to win 3-1.' Mikey Campbell on email echoes that view: 'Why has Moyes started Cleverley? Hasn't shown any talent and world class Kagawa is sitting on the bench yet again. Could come back to bite United tonight.'
After his sensational strike at Upton Park, United striker Wayne Rooney is the man the visitors must watch most closely. The England ace has scored five goals in his last five games in all competitions against City. But Danny Welbeck has been enjoying games at Old Trafford of late too - he's netted in each of his last three Premier League starts at the Theatre of Dreams.
More of your views later. Gary Neville says David Moyes will want to get through the night 'with no embarrassment', adding: 'There's not long to go in the league now, which means there's definitely more riding on this game for Manuel Pellegrini and his City players.'
Balancing it up, here's City fan Rob Chandler on email: 'I cannot wait for this game. I think it's going to be a corker. Shame about no Aguero but as a lifelong City fan, I think City will win tonight but it will be close. 3-2 to City. Nasri, Silva and Yaya Toure for City, Rooney and Welbeck for United.'
Let's get to some of your thoughts. United fan Rifat Ahmed on email says: 'I just have a strange feeling tonight that we will do something special, to show the City fans we are still the real deal. I hope to see Mata behind Wayne Rooney and not in the wider areas. I'm just embarrassed to be a Man Utd fan, not because of the players, but because of the style of play. We just don't seem to dominate anyone anymore.' He's predicting 2-0 to the hosts, with Mata and Rooney on target.
Former United midfielder Paul Scholes is in the Sky Sports studio tonight. When asked about United's struggles this season, he says: 'A big problem is that the manager doesn't know his best team yet. Away from home, they haven't been too bad at all. But when you counter-attack here (at Old Trafford) and you haven't got pace, you're going to struggle.'
Still waiting for confirmation of the City bench. But, like Moyes, Manuel Pellegrini has also made four changes to his line-up after the 5-0 home win over Fulham on Saturday. Kompany, Clichy, Navas and Dzeko replace Lescott, Kolarov, Milner and Negredo.
So David Moyes makes four changes to the United team that won 2-0 at West Ham on Saturday. In come Evra, Ferdinand, Welbeck and Cleverley. Dropping to the bench are Buttner, Fletcher, Kagawa and Young. Valencia is also among the substitutes - no sign of Nani or Januzaj, however.
Tonight's Manchester City team is as follows: Hart, Zabaleta, Kompany (c), Demichelis, Clichy, Yaya Toure, Fernandinho, Nasri, Silva, Navas, Dzeko.
Here's Manchester United's starting line-up: De Gea; Rafael, Ferdinand, Jones, Evra; Carrick, Cleverley, Fellaini; Mata, Welbeck, Rooney.
United have taken more points away from home than any other Premier League team this season (30), but only 21 out of a possible 42 at Old Trafford. With that in mind, Red Devils boss David Moyes says: 'It's been a mystery to me. We've had lots of the ball but not made it count.'
Don't forget our live TV coverage of the derby gets underway on Sky Sports 1HD and Sky Sports 3D from 7pm.
No Aguero (hamstring) for City tonight, or Matija Nastasic (knee), but Vincent Kompany is back from suspension for the visitors, who are six points behind leaders Chelsea in the Premier League table but have three games in hand. For seventh-placed United, 12 points behind City having played two games more, Chris Smalling (hamstring), Jonny Evans (calf) and Rio Ferdinand (back) are all doubtful, along with Antonio Valencia (eye). Nemanja Vidic is banned.
Of course, the most recent meeting was City's 4-1 win over United at the Etihad on Sunday 22 September. Two goals from Sergio Aguero, either side of a Yaya Toure strike, put Manuel Pellegrini's men on their way. Samir Nasri added a fourth, and Wayne Rooney's late effort for the visitors was not much of a consolation for United on the day.
Tonight is the 167th Manchester Derby. As far as league encounters are concerned, United have the edge having won 59 to City's 41. 49 of those league games have ended all square. But what does history count for? It's all about what happens when the players cross that white line...