As one of manager Sir Alex Ferguson's big-game players, Fletcher is set for a starting berth against Liverpool. The Scotland international provides United with tenacity in midfield, with his work-rate particularly hailed by his team-mates. Fletcher will aim to harry the opposition into making mistakes while his box-to-box nature makes him a difficult player to nullify.

The Serbia international has endured a tough time of things when coming up against Liverpool. Indeed, Vidic has been sent off in his last three Premier League meetings with the Reds. The pace of striker Fernando Torres has often been a problem for Vidic, who will surely be extra determined to shut out United's fierce rivals and put in the type of commanding display he is capable of.

Manchester United's charge for the title is currently fuelled by Rooney, a man playing at the top of his game yet still capable of getting better at the age of 24-years-old. Rooney has fired home 33 goals in all competitions this season, with four of those strikes coming his his last two appearances. Liverpool's defence is set for a fierce examination against the quality of Rooney.

Speaking after Thursday's win over Lille, Liverpool boss Rafa Benitez said Torres is not yet fully fit. Nonetheless, the striker has bagged four goals in his last two matches. And such form is a stark reminder of the Spaniard's clinical nature in front of goal. Torres has previously given United's defence nightmares and he will again be eager to haunt their backline with his electric turn of pace.

The Liverpool stopper faces a mean test against United's Rooney, but Carragher will be more than up for the task. Carragher is always fully committed and will play with his heart on his sleeve at Old Trafford. It is imperative Carragher ensures Liverpool's defensive line finds a balance between not playing too high and not dropping too deep, which would allow Rooney to utilise his heading ability.

The Argentine will play a crucial role for Liverpool, similar to that of United's Fletcher. However, Mascherano's positioning is likely to be a little more reserved as he aims to protect Liverpool's backline, offering a shield. As well as using his determination to break up play, Mascherano must look to close down the space between defence and midfield, where Rooney often thrives.