The Rams Player of the Year and former Manchester United full back is unhappy with the club's current financial state and wants to leave.
On Tuesday it was revealed the club's players had not been paid for last month, however The Rams claim the salary situation should be rectified by the end of the week.
It seems, though, that Higginbotham is fed up with the cash-crisis, and claims the club are in breach of contract over their financial obligations.
A statement from the player's agent on the club's official site read: "It is with regret that I feel forced into serving my notice to Derby County Football Club for breach of contract.
"I believe that it is in my interest, those of the club and our supporters that I must take this action to force some kind of conclusion to the uncertainty hanging over everyone at the club.
"I did not take this decision lightly and I have spoken with various people both inside and outside the club and they fully support my action.
"I will continue to give my usual 100 percent for Derby County and I am fully focused on the Burnley game this weekend which is vital to the players and the fans.
"I look forward to seeing the club back in a healthier state."
Warren Barton said on Wednesday that the squad was behind the club, but it would seem Higginbotham has had a re-think and served notice.
Higginbotham pledged his future to the club following their relegation last term, and may be persuaded to stay on should they prove that finances are secure at Pride Park.
