The R's had led early doors from Tony Thorpe's strike, however Leeds United loanee Jamie McMaster levelled matters shortly after.
Ian Evatt put the home side ahead after the break before Steve Palmer's goal after 63 minutes restored parity.
Despite the setback, Chesterfield regained the lead through Glynn Hurst before Mark Hudson finished off the visitors with a fourth.
Brighton stunned league leaders Plymouth Argyle with a 2-1 win at The Withdean Stadium.
Trevor Benjamin gave the hosts the lead after 12 minutes and Leon Knight doubled their advantage just after the half-hour.
Argyle tried hard to fight back and Nathan Lowndes pulled a goal back just two minutes before the end but it was too little too late for The Pilgrims.
Andrew Gurney's late strike ensured Swindon gained a point from their trip to Bloomfield Road against 10-men Blackpool.
Scott Taylor fired The Seasiders ahead early doors, but free-scoring Sam Parkin levelled matter shortly after the break.
Tony Dinning restored the home side's advantage, however Richard Wellens' dismissal coupled with Gurney's late strike ensured the spoils were shared.
Kemal Izzet rescued a last-gasp point for Colchester in a 1-1 draw against Tranmere at Layer Road.
The visitors led through Eugene Dadi's 27th minute goal, but their efforts were hindered when Micky Mellon was dismissed for receiving his second yellow card just before half time.
Rovers were looking good for the three points before Izzet snatched an 89th minute leveller.
Rushden & Diamonds secured their 11th win over the season with a comfortable 4-1 home win over Oldham.
First half goals from Rodney Jack and Onandi Lowe (pictured) put the home side in control before Jermaine Johnson pulled one back.
It proved nothing more than a consolation in the end as further goals from Andy Burgess and Paul Hall sealed an easy victory.
Barnsley snatched a late point in their bid for promotion after Kevin Betsy's penalty nicked a 1-1 draw at Notts County.
Andy Parkinson's 26th minute goal had looked enough to give The Magpies all three points , before Betsy's spot-kick, coupled with Ian Richardon's dismissal, ensured the match finished level.
Brentford pulled away from the drop-zone after a tense 3-2 home victory over Port Vale.
Jay Tabb fired the home side ahead after just two minutes, however Stephen McPhee equalised on the half hour mark.
Goals after the break from Stephen Hunt and Tony Rougier put the home side in control.
McPhee's second goal of the game late on set up a tense finish, but The Bees hung on for the points.
Stockport remain in the bottom four despite an entertaining start against Peterborough at Edgeley Park.
Curtis Woodhouse had the visitors ahead after five minutes, however an own goal from Clive Platt and further goal from Rickie Lambert put The Hatters ahead.
Andy Clarke's goal on the half hour mark was the last of the game and ensured the sides finished level at 2-2.
Meanwhile, Hartlepool's home clash against Luton Town and Grimsby's encounter with high-flyers Bristol City both fell foul of weather conditions.
Click below for match summaries:
Blackpool 2-2 Swindon
Bournemouth v Wrexham
Brentford 3-2 Port Vale
Brighton v Plymouth
Chesterfield 4-2 QPR
Colchester 1-1 Tranmere
Grimsby PPD Bristol City
Hartlepool PPD Luton
Notts County 1-1 Barnsley
Rushden & Diamonds 4-1 Oldham
Stockport 2-2 Peterborough
Click here for the latest Division Two table.
