Slough Town produced one of the shocks of the day after knocking out Walsall.
Slough Town produced one of the shocks of the day after knocking out League One outfit Walsall.Darren Wrack seemed to have have fended off any chance of a giant-killing when he levelled Ian Hodges first-half strike, but Glen Harris sunk Paul Merson's men sixteen minutes from time.
Swindon put on a fine display to see of Sheffield Wednesday 4-1 at the County Ground.
After Brian Howard and Steve Jenkins had put Swindon two up, Glenn Whelan hauled Wednesday back into the game just past the hour mark.
However, late strikes from David Duke and Christian Roberts put a real gloss on the scoreline for The Robins.
Leyton Orient eased past Dagenham and Redbridge at Brisbane Road, goals from Matthew Lockwood, David Hunt and Wayne Carlisle gave the hosts a three-goal lead, and Chris Moore's late penalty was no more than a consolation.
Colchester and Mansfield will have to try again after a 1-1 draw, Alex Baptiste cancelled out Greg Halford's opener.
Embattled Milton Keynes Dons gained some relief after edging out Lancaster courtesy of Wade Small's strike three minutes after the break.
Northampton progressed at the expense of Barnsley, Scott McGleish's goal after just five minutes proving decisive.
Notts County saw off Woking, Julian Baudet moved them ahead with a 35th minute penalty, and Gavin Gordon killed the contest with a second in the final minute.
Curtis Woodhouse was the hero for Peterborough with a last-gasp effort to knock out renowned giant-killers Tranmere.
The former Birmingham and Sheffield United man won the contest after Ryan Taylor had equalised Peter Kennedy's opener.
Rochdale's Grant Holt grabbed a double to sink Oxford United who had actually taken the lead through Lee Bradbury.
Scunthorpe continued their fine run by cruising past Chesterfield 2-0, in-form Paul Hayes grabbed the first and Ian Baraclough made the game safe.
Hereford beat non-league rivals Southport 3-1, goals from Lee Mills, Adam Stansfield and Robert Purdey ensured Terry Ferans late effort was no more than a consolation.
Ian Rush's Chester City made safe progress with a 2-0 away win at Stafford Rangers thanks to goals in each half from Cortez Belle and Kevin Rapley.
Stockport put their league woes behind them to cruise into the next round at the expense of League One rivals Huddersfield.
Ashley Williams and a Warren Feeney double put Sammy McIlroy's side in complete control, and Pavel Abbott's 13th goal of the season was too little too late for The Terriers.
Doncaster made light work of a tricky looking trip to Tiverton Town and triumphed 3-1.
Michael McIndoe, Nick Fenton and Gregg Blundell put the hosts in an unassailable lead, although Steve Winter did pull one back with a last-minute penalty.
Wycombe were made to struggle by the smallest team still left in the competition, Coalville Town, but eventually came through with a 71st minute goal from Roger Johnson.
Yeading beat Halesowen 2-1, a David Hayward own-goal and a DJ Campbell penalty were sufficient and sandwiched Alex Cowley's effort.
