By Steve Luckings
Last Updated: 01/01/70 1:00am
Wilfred Bouma was first on the scoresheet with a goal inside of two minutes but it took until the 54th minute for PSV to double their lead through John de Jong with star striker Mateja Kezman sent off in between.
Danish winger Dennis Rommedahl added the third, before Arjen Robben put the final nail in the coffin to leave ADO still struggling near the foot of the table.
RKC Waalwijk suffered defeat on their travels as they fell 1-0 to Heerenveen.
Richard Knopper scored the only goal of the game on 45 minutes which was enough to see off the threat of RKC.
NAC Breda played out a 2-1 defeat to FC Utrecht at FujiFilm-Stadion.
Johan Elmander scored for NAC just before the break before Donny de Groot conjured up a leveller for the visitors with 11 minutes remaining.
The game looked to be heading for a stalemate before Marcel Koning put through his own net for a late winner for the visitors.
Roda JC Kerkrade were also successful on their travels thanks to a 2-0 win over Willem II Tilburg.
Endrissa Sonko made it 1-0 at Willem II Stadion after 35 minutes before Aroune Kone made sure of the points two minutes from time.
AZ Alkmaar continued to keep pace with Ajax and PSV at the top thanks to a win over NEC Nijmegen.
Peter Wijker scored inside 60 seconds before Ali Elkhattabi did similar just before the full time whistle.