PSV are in second spot but lost further ground on leaders Ajax by going down by a single goal at the Philips Stadion.
Eby Smolarek was the difference between the two sides and his 13th minute effort was enough to give the visitors all three points.
AZ Alkmaar suffered a blow to their European hopes as they went down 2-1 at home to Utrecht.
Michael Buskermolen gave the hosts the lead three minutes after half time, but Hans van de Haar restored parity with his strike ten minutes later.
Sandro Calabro then popped up to grab a late winner for Utrecht with seven minutes left on the clock.
Ajax increased their lead at the top with a 4-2 victory at home to Roda.
Nicolae Mitea gave the hosts the lead after 26 minutes and Yannis Anastasiou then grabbed a double and Iwan Redan pulled one back to make it 3-1.
Mark Luypers quickly made it 3-2 but Steven Pienaar popped up to make the game safe at 4-2 with eight minutes left.
Willem II grabbed a 1-1 draw at RKC Waalwijk as Joris Mathijsen cancelled out Said Boutahar's opener.
Vitesse Arnham sealed a late 1-0 win at home to ADO Den Haag courtesy of a penalty from Ruud van Knol four minutes from time.
Match Summaries:
AZ v Utrecht
Ajax v Roda JC
PSV v Feyenoord
RKC v Willem II
Vitesse v ADO Den Haag
