By Graeme Bailey
Last Updated: 01/01/70 1:00am
Before the start of play both teams were on 46 points, with Ajax having a game in hand and so the game in the capital would have a major bearing on where the title goes in May.
PSV silenced the home crowd just before half time when Jan Vennegoor of Hesselink pounced.
Ajax, though, were on level terms just five minutes into the second period when the outstanding Wesley Sneijder grabbed the equaliser.
Coach Ronald Koeman was still not happy and he introduced Romanian Nicolae Mitea and Rafael van der Vaart - who surprisingly started from the bench.
Just before the hour mark Koeman's changes had the desired effect.
It was young Mitea who pounced to grab his fourth goal of the season - his second in two games after coming on a scoring against Den Haag last week.
Ajax held on to claim all three points and are now odds-on favourites to bring to the title back to the club.
Third place Feyenoord failed to close the gap on PSV in second, after they were held to a goalless draw by Vitesse Arnhem at The Gelredome.
Vitesee remain third from bottom, but the draw with the Rotterdam giants will surely boost their hopes of survival.
Willem II moved into the top six after beating Den Haag 1-0.
The only goal at The Willem II Stadion came just after half time when Anour Hadoir struck.
Den Haag's misery was compounded in the final minute when Kofi Mensah was dismissed for his second bookable offence.
Groningen are now six points clear of the drop zone after they secured a 2-0 win over NEC Nijmegen - which lifted them above their opponents.
Avrid Smit opened the scoring on the hour for the home side, before Chris De Witte killed the game off in the final minute.