A brace of own goals from Remco Schol and Albert-Michael Yobo helped PSV to their impressive victory, along with goals from Johann Vogel and Arjen Robben (pictured) helping Guus Hiddink to put pressure on leaders Ajax.
The next two sides occupying the bottom three, Ado Den Haag and Viteese Arnhem, met at Zuiderpark and the hosts took the lead just before the half hour through Peter Hofstede, but for Emile Mbamba to grab a point for Vitesse 15 minutes from time.
Willem II moved up into fifth place in the table with a comfortable 3-0 win at home to NEC Nijmegen, thanks to goals from Romano Denneboom, Tom Caluwe and Bart van den Eede.
Twente took the lead at home to NAC Breda with Collins John's 51st minute strike, but for Arne Slot to level for the visitors who looked good for a point until Kim Christensen notched the winner for Twente two minutes from time.
Match Summaries:
ADO Den Haag 1-1 Vitesse Arnhem
FC Zwolle 0-4 PSV Eindhoven
Twente 2-1 NAC Breda
Willem II 3-0 NEC Nijmegen
