By James Pearson
Last Updated: 01/01/70 1:00am
Venlo gave a good account of themselves in the opening half conceding just once, Theo Janssen's (pictured) strike after 42 minutes.
However, the wheels fell off the wagon after the break with further efforts from Aleksandar Rankovic and Matthew Amoah putting Vitesse in control.
Nicky Hofs and Stijn Schaars put the icing on the cake with two more goals in the final ten minutes of the contest.
Heracles Almelo remain top of Group B following a 1-0 away victory. Richard Roelofsen netted the only goal after 66 minutes.
Almelo have been in blistering form in the play-offs, with the side yet to even concede a goal following their opening 4-0 win over Volendam.
De Graafschap are in second place after Loic Loval's goal after just three minutes was enough to sink Volendam and push the side one step closer to relegation.
Helmond Sport and Sparta Rotterdam secured a point apiece following a thrilling 2-2 draw.
Dennis Schulp bagged a brace for Helmond, however his effort was not enough as Danny Koevermans and Kiran Bechan scored for Sparta.
Helmond Sport 2-2 Sparta Rotterdam
Vitesse Arnhem 5-0 VVV Venlo
Excelsior Rotterdam 0-1 Heracles Almelo
Volendam 0-1 De Graafschap
Click here for the final Eredivisie table.