Last Updated: 23/02/13 5:03pm
And the final whistle goes with the Red Devils well and truly cementing their place at the summit and piling the pressure on Manchester City, as well as heaping misery on the struggling Hoops.
Samba pushing up in attack and running eagerly down the left, but it's probably too little, too late for Redknapp's troops.
Three minutes of added time is signaled with United looking unfazed and closing in on a 15-point lead at the top of the standings.
Samba delivers a good header on goal off Taarabt's free-kick from the left that draws a left-legged save from De Gea.
Giggs feeds Welbeck from the left inside the area, but the latter is legally bundled over before he can his shot off.
United making it look easy as they breeze up field, Giggs pulling the strings for the league front-runners.
United now in cruise-control, Giggs taking a dink at goal from outside the box that strikes the crossbar, Nani shot on the rebound from the edge of the box on the left skied high over the bar.
GOAL! Perfect finish from the evergreen Giggs after a good pass into the box from the edge of the area by Nani.
Hoilett feeds Remy, who then feeds Taarabt, but his first touch is poor and gives possession back to Untied.
Welbeck receives a good ball forward from Rooney, but after creating space for himself to shoot, he labours with his strike and Hill gets back to block.
Taarabt maybe a touch frustrated now as his ball forward for Remy is too strong and straight into touch.
United force their way back inside QPR's half of the pitch, but Samba does well this time to clear the ball without incident.
Samba making a little a bit of a hash of his eventual clearance at the back with Rooney chasing hard.
United take a quick free-kick and Rafael looks to deliver the ball to the far post, but it's too deep for Welbeck and Valencia.
United's Ferguson maybe making the changes now as an insurance policy with the return leg at Old Trafford against Real Madrid coming up in the week.
Traore does well to dispossess Nani in the box on the right, but loses the ball back to the United man, only to snatch it back once more and this make the clearance.
Vidic receiving a bit of treatment for a cut above his nose, but the United skipper is soon back on the park and raring to go.
The R's doing well to carry the ball down the middle and then out to the flanks for Townsend, Mackie and the new man Remy to create something.
United working hard to force their way up field, but Armand Traore is holding his position in defence to intercept a pass for QPR once more.
Changes for both sides as Zamora and Hernandez leave the field for Loic Remy and Wayne Rooney respectively.
Samba does well to intercept Young's pass as the United flyer tries to feed Welbeck on the wraparound.
Taarabt goes down under the challenge on the edge of the area, and gets possession for United, but the home fans voice their displeasure with the referee's call to play on.
Young, again, working hard down the touchline to retain possession under pressure, getting the ball away for Welbeck, who eventually gives it away far too easily.
Hernandez, again, on the ball and running strong, but loses the ball out in front before he can wind up to shoot.
QPR really showing some enterprising play going forward with Mackie seemingly involved with every movement.
Townsend does well to get around Evra and whip the ball in from the right, but Mackie's diving effort with the head misses the cross.
Hernandez with a good run down the left, but he finally dispossessed on the edge of the box before getting a shot away.
The R's trying to find their way into the match now, but area struggling to retain possession for a more than a minute.
Welbeck and and Young work well for the latter to deliver a decent ball into the area for Nani, whose free header almost is fumbled but gathered up by Cesar.
QPR don't have many goals in them, which is why they're 16/1 to overturn Man Utd's lead for three points. Javier Hernandez is 9/2 to score next while United are 6/1 to win 3-0.
United are in cruise control now. Robin van Persie is 3/1 to score the next goal and Javier Hernandez is 9/2.
Nani feeds Hernandez in the box, but 'Chicharito' goes to ground trying shrug off Clint Hill, only for the referee to wave play on, and then blow time for the break.
The Red Devils looking to contain a determined R's down the left flank, the ball just about cleared down the touchline to safety.
After some stoppage in play, the match resumes with two minutes of added time shown by the touch official.
QPR look to launch an attack with United down to 10-men, Evra staying down after Townsend's loose boot catches the Frenchman on the cheek.
Good ball into the are from the set-piece from Giggs sees Vidic rise unchallenged and get in with a free header on goal that is just off target.
Taarabt's deep ball for Townsend inside the box is swiftly hacked clear by Carrick, but the Hoops are still pushing up in earnest.
Van Persie tries to strike on the volley after Michael Carrick's great ball from midfield into the area, but Cesar produces a fine stop to steer the ball away from goal.
Deep ball from the set-piece to left for Samba, but his header isn't on target and the danger is cleared.
Vidic gives the ball away to Townsend, who hurries towards and then feeds Zamora, but his shot on goal is blocked for a corner.
Zamora beats Rio Ferdinand in the air to feed Taarabt, but his shot on goal skids way off target and into touch.
Andros Townsend does well to create some space for himself on the right, but his shot flies way over and into the stands.
The Hoops working the ball through the phases, but some strong defensive work from Nani sees the winger poach possession and look to set Van Persie on his way.
With United in front on the scoreboard, QPR are forcing their play with more risky passes and over exuberance at the back with their clearances.
Young tries his outmost to keep the ball in play down the left as he shows off some good ball-skills, but ultimately loses possession into touch.
Jamie Mackie fails to find his target from the left after a ball into the box from the right by Bosingwa bounces awkwardly for the United defence.
Giggs with a run down the left and then whipping the ball into the box, but the Hoops defence does well to deal with the numbers in the area and clear the ball.
Unlucky for QPR who now have to claw their way back into the match against the Premier League leaders.
GOAL! An absolute show-stopper from Rafael as the full-back whacks the ball into the top corner on the volley from outside the box on the right.
The R's push forward through Taarabt, but Vidic does well to force them back with some tough defending.
Hernandez almost makes Chris Samba pay, the R's defender dispossessed by Nani who feeds his team-mates, but the striker's effort on goal is poor.
An instinctive headed flick-on on goal from Hernandez just goes over Cesar's goal, but the shot-stopper still tips it out for a corner. United, however, fail to make much of the set-piece.
Taarabt with some positive play up front for the R's, creating a small space to shoot from the right, but only into touch.
United, again, working the left side as Giggs tries to feed Hernandez this time, but the pass is too long.
Van Persie tries to head the ball forward for Nani to chase out on the left, but it bounces out of touch.
Good ball in from Young to find Nani, but the Portuguese winger's glancing header on goal sails wide of the right upright.
United once clear the ball from the set-piece abd look to launch an attack of their own through Ryan Giggs, with the Hoops eventually giving away a free-kick out on the left after Bosingwa fouls Nani.
The Hoops back inside United's half and probing down the right flank through Jose Bosingwa and earn themselves a corner-kick.
Good control from Adel Taarabt as the Moroccan pushes up strongly, but his low shot is easily gathered by De Gea.
Javier Hernandez looks to feed Robin van Persie out on the left, but the Dutchman is flagged for off-sides.
The home side with much of the play and look more positive on the ball than what has been seen of them for much of the season.
United hold their defensive line as Ashley Young clears the danger from the set-piece, injuring his foot in the process.
Julio Cesar launches ball from the back up field for Bobby Zamora to control as the hosts work the ball around in search of an opening.
I have got a really bad feeling about this one, however hopefully United can get a win. I fancy Hernandez to back a brace, his pace and movement could be too much for the QPR center halves. Im going 3-0 United. Dominic Stonebridge
I think this will be an easy game for man utd. They will be 15 points clear in no time! from Ryan Simpson in mnchester
Feel free to e-mail your thoughts or predictions to email@example.com and we'll publish as many of them before - and during - the game as possible.
QPR haven't beaten United at home since 1989, and Sky Bet punters are not convinced they can end that run as the large majority of the pre-game money has been placed on an away win at 8/15 on. With just eight goals scored at home this season, No on Both Teams to Score at evens seems a banker, but United To Win To Nil at 13/8 is a similar option with much better value.
United, meanwhile, go into the game on the back of a 16-game unbeaten run in all competitions, having registered their last defeat back in December against Romanian outfit Cluj in the Champions League. A win for Sir Alex Ferguson's side in the capital will see them go 15 points clear at the summit.
QPR have shown commendable resistance since Harry Redknapp took over the reigns from Mark Hughes in November, although they are still battling to stave off relegation. The R's had gone on a four-match unbeaten run in the league, before eventually succumbing to Swansea in the 4-1 away defeat a fortnight ago.