Last Updated: 02/04/14 9:41pm
Real Madrid will take a 3-0 lead with them to the Westfalenstadion for the second leg, in which Dortmund will be hoping the returning Lewandowski can inspire a famous comeback. Thanks for following the game with me. Stay here for report, reaction and plenty more from the Bernabeu.
Aubameyang attempts to cut inside Carvajal on the left side of the box but the Real Madrid defender reads it and intercepts.
Four added minutes will be played as Hummels slides in to deny Morata with a perfectly-timed challenge.
Hofmann has two attempts at delivering from the right but Real Madrid stand firm and clear on both occasions.
Bale runs from his own half and beats three challenges before firing over when he gets in the box. A great run from the Welshman.
Casemiro replaces Ronaldo, who tonight scored his 14th goal in eight Champions League appearances this season and his 64th in 100 career games. He saunters down the tunnel, with the change seemingly made out of precaution.
Jojic hits the floor in the box after a challenge by Alonso but Dortmund don't even bother appealing for a penalty.
Great save from Casillas as he springs from his line to block Reus shot but the referee has blown already for a handball in the build up.
Weidenfeller saves from Benzema again, this time stooping to collect the Frenchman's deflected shot from the edge of the box.
The substitute is immediately involved, demanding a penalty after losing a battle of strength with Coentrao. Hofmann is not happy to be told by Ramos to get up but after a word from the referee, everyone is friends again.
Benzema fires a splendid half-volley goalwards from the edge of the box but Weidenfeller reacts by touching the ball over the bar. The corner finds Ramos, but his header is straight at the Dortmund keeper.
A fabulous block from Pepe denies Mhkitaryan a certain goal after Casillas parried a Reus cross in the six-yard box. Real clear the corner and break, but Bale can't find Benzema.
Modric wins the ball deep in the Dortmund half and puts through Ronaldo, who takes it to the side of Weidenfeller and finishes in almost one movement. Fine pass, great finish.
Mhkitaryan fires wide after another counter by Dortmund. Reus attempted to play in Aubameyang but the pass forced him wide. Aubameyang then chose to feed Mhkitaryan, but his shot from inside the box hits the side-netting.
Ronaldo skins Hummels on the right before getting to the line and squaring for Benzema but Sokratis somehow gets the ball over while lying on the floor, two yards from the goal-line.
Weidenfeller comes to the very edge of his box to gather a long pass from Ramos, who tried to pick out the run of Bale from 60 yards.
Aubameyang wastes Dortmund's best chance so far, dragging a shot wide from the right of the box after Reus had driven at the Real defence. It was a poor finish. Lewandowski's absence is being felt by Dortmund.
Bale gets through on Weidenfeller again and tries a similar toe-poked finish but the Dortmund keeper stretched out his right foot to block. Great pass from Modric to play in Bale.
Real Madrid take a 2-0 lead into the break. Dortmund finished strongly but Casillas has not been stretched. How do Klopp and Dortmund react?
Durm is down after catching one of Bale's elbows in the ribs. After a breather, the Dortmund left-back is fit to continue.
Reus tries a shot from the edge of the box which Ramos has to block. Dortmund retrieve the loose ball and switch play to Durm, who wins a corner.
Aubameyang receives a pass from Mhkitaryan before turning and shooting from 20 yards. The ball flies high and wide, much to the disgust of his manager.
Ronaldo stretches to reach a Ramos pass from the left after a neat move but the ball is just out of reach for the Real Madrid star. Dortmund clear but at the expense of a corner, which is cleared easily.
Bale fools two defenders with a Cruyff turn on the left before feeding Carvajal. The full-back delivers a cross which Benzema wins but his header drops wide.
Sahin tries to drop a ball over the top for Reus but the pass is too heavy. Having seen a replay, Dortmund can consider themselves somewhat unfortunate not to have had a penalty but Pepe escapes.
Mhkitaryan wants a penalty after being barged over by Pepe but Clattenburg gives nothing. The ref didn't seem to have a good view but play continues so Dortmund have no time to protest.
Dortmund launch a swift counter attack, with Grosskreutz leading the charge. The midfielder opts to shoot early from outside the box but Casillas drops to his right to make a comfortable parry.
Bale does indeed take it and he hits a delightful dipping effort over the wall, with Weidenfeller having to get across and make an almost identical save to the one which denied Ronaldo earlier.
Bale wins a free-kick just to the left of centre, around 25 yards out. He looks like he fancies it...
Alonso wins a tackle deep in the Dortmund half, with the ball rolling to Isco on the edge of the box. The young Spaniard takes two tight touches before rolling a shot into the bottom corner, out of Weidenfeller's reach.
Aubameyang runs at Ramos on the right and delivers in an inviting cross, but none of his Dortmund team-mates had got forward in support.
Sahin has a shot from 30 yards, but Casillas wanders across to block before tidying up by collecting the loose ball.
Aubameyang attempts a bicycle kick from Piszcek's cross but Pepe is on the scene to block. The Real Madrid defender gets a whack in the face in the process. After treatment, he is fine to continue.
Weidenfeller in action again, sprinting from his line to gather Ronaldo's pass as Benzema looked to pounce.
Hummels blocks a volley from Ronaldo at the expense of a corner. Pepe leaps highest and heads goalwards, with Weidenfeller and a defender getting mixed up before they eventually clear.
Great save from Weidenfeller. Ronaldo smashes a dipping, curling shot from 30 yards out, with the Dortmund keeper leaping up to palm the ball over the bar. The resulting corner is cleared.
Ronaldo does test Weidenfeller this time, with a 25-yard drive. The Dortmund keeper dives to his left to parry, with a yellow and black shirt collecting the loose ball.
Dortmund win a throw-in deep in the Madrid half to give their defence a breather. Nothing comes of it, though, and Real clear their box.
It's all Real Madrid. Bale drives at the Dortmund defence before finding Ronaldo on the left. Ronaldo teases two defenders before cutting back inside but he is robbed before he can unleash a shot.
Bale has another chance after Coentrao's deep cross reached him at the far post. His first header was cleared before his mis-hit volley eventually rolled into the gloves of Weidenfeller.
Benzema held off two defenders on the right before playing in to Carvajal, who in turn passed on to Bale. The Welshman took a touch before poking past Weidenfeller. Great start for the hosts.
Early corner for Dortmund after Aubameyang gets in behind down the right, forcing Coentrao to concede the set-piece. Ronaldo, though, comes back to head clear the delivery.
The teams have been led on to the pitch by English referee Mark Clattenburg.The unmistakable Champions League anthem is playing and anticipation is building. Any last-minute predictions?
Little optimism out there for Dortmund, it would seem. George Nelson has tweeted: "Hi Ian. Looking forward to a comfortable Madrid win tonight. Can see 3-0, with Ronaldo 2 and Bale with the other! HALA MADRID."
Adam Gillis is predicting plenty of goals - all for Real: "I will keep it short and sweet: 5-0 to Madrid."
Dortmund, though, do not have a good record in Spain, where they have won only 1 of their 11 previous games. Another scary stat for the Klopp and his crew: Ronaldo is playing in his 100th Champions League game, having scored 63 goals. Incredible when you consider that he failed to net in his first 26 games in the competition while at Manchester United.
Both sides come into tonight's game on the back of domestic victories. Real Madrid thumped Rayo Vallecano 5-0 at the weekend, while Reus fired a hat-trick as Dortmund came from two goals down to win 3-2 at Stuttgart.
A prediction from Chris Green in Huddersfield: "Real Madrid to win 3-1, with Modric and Ronaldo (2) scoring the goals." How would Dortmund view two-goal deficit with an away goal ahead of the second leg?
The loss of Lewandowski undoubtedly weakens Dortmund, but Ancelotti is taking nothing for granted: "Lewandowski is a big loss for them. But they have Pierre-Emerick Aubameyang, who can take advantage of Lewandowski's absence. He's a great player and I remember him well from last year when he was at St Etienne."
Dortmund coach Klopp claims his side will be really up against it tonight: "Given our budget and the injuries we've got, there's no doubt we're the underdogs."
Goals are almost a certainty at the Bernabeu. Last season's meeting was settled by an aggregate score of 4-3 in Dortmund's favour, while hosts Madrid have netted in 33 consecutive games - a Champions League record. Despite the absence of the suspended Lewandowski, the Dortmund side retains plenty of creativity and firepower with the likes of Aubameyang, Mhkitaryan, Reus.
Having seen those line-ups, which way do you see tonight's first-leg going? Will Real Madrid do enough to put Dortmund out of reach, or will Jurgen Klopp's depleted side keep out the likes of Ronaldo and Bale? Let me have your thoughts throughout the evening. You can reach me via email firstname.lastname@example.org or find me on Twitter: @IanWatson1.
Borussia Dortmund: Weidenfeller, Piszcek, Durm, Sokratis, Hummels, Kehl, Sahin, Grosskreutz, Aubameyang, Mhkitaryan, Reus
Real Madrid: Casillas, Pepe, Ramos, Coentrao, Ronaldo, Benzema, Bale, Xabi Alonso, Carvajal, Modric, Isco.
Tonight's clash is a repeat of last season's thrilling semi-final, which resulted in Dortmund progressing to the all-German final. Will Madrid gain their revenge?