Last Updated: 06/04/13 2:57pm
Do Prado spurns a golden chance to make it 3-0 at the death, with a wonderful run from Clyne taking him to the byline, as his cut back finds the striker who wildly blazes over the bar.
A poor touch from Morrison allows Davis in, with a ricochet saving the defender as the ball rolls back to Federici.
Lambert is found offside from Lallana's ball this time, with the Royals fans starting to head for the exits as the game draws to an end.
Overly-aggressive hussling from Hunt on Schneiderlin sees another free-kick conceded, and another minute killed in Saints' minds as they look to see out the match.
Rodriguez battles on as he takes on Mariappa, but the defender gets a touch to the ball, driving him away from goal as Reading eventually win a throw-in.
Karacan hacks away following Rodriguez's hopeful ball from the byline into Lambert, with the crowd somewhat quitened following that neat spell from the visitors.
Lallana finds the offside flag thwart his progress after looking to meet a ball down the right, but Lambert regains the ball for the visitors following the free-kick.
Impressive possession play from Southampton sees them keep the ball, frustrating Reading, and dousing some cold water on the momentum they have built over the last five minutes.
Another McAnuff corner comes in, but Boruc does much better this time, confidently claiming the ball ahead of the Reading centre-backs.
More maverick goalkeeping from Boruc, whose juggling skills see him eventually gather the ball from a free-kick, with Reading finally upping their assertiveness in the final third.
McAnuff takes on Shaw, creating a yard to shoot, which he does, but his rather tame effort is cleared away, with Reading fans finding their voices again following that incredible Boruc incident.
Controversal scenes as Le Fondre heads the ball on, with Boruc incredibly catching it and taking the ball backwards, eventually pushing it away in his bid to prevent it crossing the line!
Could that be the final nail in Reading's Premier League coffin? A sublime ball from Schneiderlin sees Mariappa caught out of position, with Lallana found, who scores his 50th Saints goal with a neat finish past Federici.
A delicious ball to the back post from Robson-anu sees Boruc come out, but he initially spills the ball, before charging through Karacan to eventually retrieve it.
An audacious attempt from Rodriguez, 30 yards out, sails harmlessly wide, but it remains all Saints right now and Reading need to up their urgency if they are to carve out an equaliser.
Close control from Davis sees Saints carve another attack out, but this time as Lallana crosses in, Morrison makes the intercepting header.
Lovely football from Saints, with Cork and Scheneiderlin involved, sees them progress, but Shaw is penalised for his pressure on Gunter which results in a free-kick.
Kelly does well under the threat of Davis, who was supported by Cork, with a lovely flick on from Lambert setting away Rodriguez who can't poke the ball past Boruc as a corner is awarded Saints' way.
Le Fondre takes aim from the edge of the area, with his half-volley narrowly aimed above the bar as both teams continue to threaten in the final third.
So close to 2-0 for Southampton, as Rodriguez creates a yard for himself, driving the ball across goal with Ramirez unable to poke the ball from close range after sliding in.
A determined Robson-Kanu sees his efforts rewarded as Reading win a corner following a timely sliding tackle from Shaw.
Boruc claims the delivery impressively, especially as he collided with Robson-Kanu in the process, taking a knock, but seemingly fine following the altercation.
Cork tackles Karacan, which results in a free-kick to the hosts, who play the free-kick short as McAnuff wins a corner for his side.
Guthrie directs the ball forward, but Hooiveld tracks the run of Le Fondre and covers accordingly to reclaim control of the ball.
Gunter is hussled by Rodriguez, who continues to impress, but remains composed before clearing the ball away from danger.
A succession of long balls and headers eventually results in a terrific ball in from Lambert to Davis, with the midfielder unable to finds the net as he pokes the ball straight into Federici's arms.
Kelly delivers for Reading, with Karacan keeping the attack alive, before his cut back to Leigertwood sees Davis slip in to intercept.
McAnuff's corner is cleared away by Saints, but the Royals resume their pressure from the corner, with Guthrie's thunderous drive colliding with Hooiveld.
Gunter knocks the ball down the line, but as Shaw clears away, McAnuff is found down the left, with his delivery taking a touch which makes it easy to hack away for Yoshida.
Rodriguez advances into the Royals' penalty area, with his chip towards Lambert seeing the ball knocked back across the penalty area before Morrison heads away.
Davis slides in to concede a throw-in, with Reading looking for one last push to claw what would be a massive equaliser before half time.
Lambert speculatively knocks the ball long for Rodriguez, which isn't successful, but this front three of Southampton are really causing problems for Reading at the moment.
Two more incredible chances for Southampton, as Rodriguez's surging run sees a shot parried by Federici, before Ramirez fluffs his lines from the rebound.
Lambert battles with Guthrie, but is penalised for his role by the referee. Reading can't capitalise though, as Akpan's quick free-kick catches Guthrie off guard and results in a Saints throw.
Ramirez looks for Rodriguez once again, this time with a delicate chip, but it carries a bit too much pace for the striker as Federici rushes out.
Close control from Guthrie sees him evade two tackles, but his delivery is too long for Le Fondre and in the end it's a simple claim for Boruc.
Rodriguez hits the bar! A sublime through ball from Ramirez finds the striker, whose vicious left-footed effort cannons off the woodwork as Reading are let off the hook on this occasion.
Reading look to respond instantly, as an acrobatic effort from Le Fondre sees his overhead kick direct the ball over the bar from a McAnuff corner.
What an important goal this could be, as Rodriguez slides into Federici, which may have been deemed a foul, with a double ricochet steering the ball into the net following Davis' chip. 1-0 to Saints!
Another chance for Ramirez, but it's another chance not taken as Shaw's header is knocked into the forward's path, who directs his header wide from just inside the penalty area.
The offside flag denies Southampton this time, with Rodriguez a yard ahead of Mariappa in his attempt to meet Lambert's delivery.
Davis snuffs out McAnuff's threaded ball into Le Fondre, with Saints working the ball forward to Rodriguez, whose shot cannons straight off Mariappa.
With Mariappa back on the field, play resumes as Rodriguez knocks the ball back to Federici, whose boot upfield sees Hooiveld beat Le Fondre in the air.
Mariappa takes a crunching in a collision with Hooiveld, with the defender's boot catching the Reading defender in the face as he noew receives treatment.
Good covering from Mariappa prevents Clyne latching on to Davis' through ball, with Ramirez dragging a shot wide moments later as both sides continue to create chances.
Saints look to maintain control of the ball after that blitz from the hosts, with Shaw whipping in from the left, finding Lambert, who can only poke the ball wide.
This is much better from Reading, with Mariappa's header drawing a wonderful diving save from Boruc as the chances continue to pile up for the hosts.
Penalty claims now, as Robson-Kanu is felled under Hooiveld, with the referee indicating he believes the defender got a touch on the ball.
What a chance for Reading. A goamouth scramble ensues from the free-kick, with Le Fondre presented a golden opportunity to find the net, which he spoons well over the bar. A really bad miss from the striker.
Neat work from Guthrie sees Hooiveld lured into making the tackle, which results in a free-kick for the hosts.
Le Fondre takes on Shaw, earning a throw-in for his side, with Robson-Kanu eventually crossing in as Boruc claims easily at the near post.
Lambert speculatively crosses in from the left, with no team-mate in sight at the far post, but Saints resume their attack through Davis, whose cut-back to Ramirez is intercepted by Morrison.
Who can break the deadlock here? Rickie Lambert is the 9/2 favourite to score first with the Saints 5/4 to pick up the points, while Adam Le Fondre (6/1) represents the greatest threat for Reading, who are 9/4 for the victory.
Reading clear as far as Cork, who finds Shaw once more, with another sterling tackle from Kelly this time ensuring only a throw-in is conceded.
Rodriguez hogs the byline before Shaw offers support, with Gunter's charging tackle resulting in a Saints corner.
As Pochettino issues instructions to his side, Ramirez remains at the heart of Southampton's attack, before being closed down by Guthrie as the ball is played back to Yoshida.
Top skill from Ramirez sees him retain the ball under pressure from Akpan. After further link-up with Lambert, the forward takes aim from range but directs his shot well over the bar.
After a failed Reading attack, Ramires collects and looks to progress down the right, with his delivery directed towards Lambert at the far post before Morrison stabs the ball away from goal.
Le Fondre looked to time his run from Guthrie's through ball, but as Hooiveld pushes up, the striker is caught offside.
Wonderful work from Le Fondre sees Reading earn a corner, with Boruc confidently snatching the delivery in the air ahead of the oncoming Morrison.
Hooiveld covers ground terrifically to prevent Gunter advancing past him down the right, with the visitors reclaiming the ball from a Reading throw-in as Ramirez collects.
Solid defending from Yoshida, under the threat of Le Fondre sees the defender win a throw-in for his team, but good pressure in the corner from the Royals sees Robson-Kanu reclaim the ball, with his delivery cleared by Hooiveld.
Gunter clatters into Rodriguez as the forward looked to slip past him down the right, resulting in a Saints free-kick.
Big early chance for Reading, as a Gunter free-kick from the right lands on the head of Morrison, who fires over the bar from 10 yards.
A quick Saints counter attack led by Ramirez sees a delivery come in from the right, but Lambert is caught a yard behind the flight of the ball as it rolls out of play.
The players shake hands and we're momens away from kick-off now, as Nigel Adkins receives a warm applause from the visiting Saints fans following his arrival to the field.
Jake Wilson tweets: "I can see a great match today. 2-0 Southampton. Would like to see Reading stay up, but I can't see it happening."
Chris Green writes: "This match is going to be cracker and I hope there is going to be lots of goals for us to enjoy. If Reading lose this afternoon, they will go down because their hopes of survival will be all but over. Southampton have the better players but this does not mean that they will dominate because Reading have good players too. I think this match will be a tie encounter but I think Southampton will win this 2-1."
Reading manager Nigel Adkins makes five changes to his side. Adam Federici returns in goal after an ankle injury, while Sean Morrison, Chris Gunter, Hope Akpan and Adam Le Fondre come in after the 4-1 defeat at Arsenal. Saints boss Mauricio Pochettino makes one alteration at the Madejski Stadium, with Gaston Ramirez coming in for Jason Puncheon.
Reading: Federici, Gunter, Kelly, Mariappa, Morrison, Karacan, Akpan, Guthrie, McAnuff, Robson-Kanu, Le Fondre. Subs: McCarthy, Harte, Pearce, Leigertwood, McCleary, Pogrebnyak, Hunt.
Southampton: Boruc, Clyne, Yoshida, Hooiveld, Shaw, Schneiderlin, Cork, S Davis, Ramirez, Lambert, Rodriguez. Subs: K Davis, Fonte, Fox, Ward-Prowse, Lallana, Guly, Puncheon
Good afternoon everyone and welcome to the crunch Premier League relegation clash between Reading and Southampton. With Reading seven points from safety, victory at the Madejski is imperative for the home side today, with the clash holding further intrigue as it marks Nigel Adkins' first home in charge of Reading against his former club. Send your e-mails today to firstname.lastname@example.org or @JWoodfield365