Gaston Pereiro was PSV Eindhoven hero as he scored twice in a 2-1 win against previously-unbeaten Eredivisie leaders Ajax.
There were Eredivisie wins for both Ajax and PSV on Saturday, while second-placed Heracles slipped to defeat.
Ajax returned to the top of the Eredivisie with a 2-0 victory over Excelsior on Sunday.
There were wins for Napoli, Borussia Dortmund and Marseille on matchday one of the Europa League.
Wout Weghorst scored the only goal as high-flying Heracles beat ADO Den Haag 1-0 to climb to second in the Eredivisie.
Mimoun Mahi scored a couple of late goals as Groningen beat Excelsior 2-0 to claim their first win of the Eredivisie season.
Michael de Leeuw rescued a point for Groningen in a 1-1 draw with Twente in the Eredivisie on Wednesday, as NEC beat Excelsior 1-0.
PSV Eindhoven clinched the Dutch Super Cup with a comfortable 3-0 triumph over Groningen in Amsterdam.
QPR have continued to reshape their squad ahead of the new season by signing forward Tjaronn Chery.
Southampton, Swansea, Bournemouth and West Ham all registered wins, while Crystal Palace and Sunderland lost on Saturday.
AZ claim a Europa League place at the expense of Feyenoord, who were consigned to the play-offs for a place in Europe.
NAC Breda face a relegation play-off, while Manchester United-bound Memphis Depay scored for PSV.
AZ Alkmaar remain in contention to clinch a Europa League berth from the Eredivisie after a 2-0 win at FC Twente.
Feyenoord moved a step closer to qualifying for the Europa League after a 2-2 draw at Willem II Tilburg in the Eredivisie.
Five-star PSV close in on Dutch title after comprehensive victory at FC Twente, while Heracles grab dramatic late win
PSV Eindhoven suffered a bump on the road to a probable Eredivisie title as they lost 2-1 at Feyenoord on Sunday.
Defender Nicolas Isimat-Mirin scored a rare goal to hand leaders PSV a nervy 2-1 home win over Groningen.
Ajax staged a late rally to beat PSV Eindhoven 3-1 on Sunday to give their faint title hopes a boost.
Feyenoord slipped 20 points behind leaders PSV in Eredivisie after a 2-0 defeat at lowly Heracles on Saturday.
AZ Alkmaar inflicted a second league defeat in four days upon Ajax as they registered a 1-0 win at the Amsterdam ArenA.