Gaston Pereiro was PSV Eindhoven hero as he scored twice in a 2-1 win against previously-unbeaten Eredivisie leaders Ajax.
Feyenoord moved up to second in the Eredivisie with a 2-0 victory over PEC Zwolle while FC Twente ended their winless start.
Heracles Almelo moved to the top of the Dutch league with a 2-1 win over champions PSV Eindhoven at the Polman Stadion on Saturday.
There were wins for Ajax and Feyenoord in the Eredivisie on Sunday, while FC Twente slipped to defeat.
Michael de Leeuw rescued a point for Groningen in a 1-1 draw with Twente in the Eredivisie on Wednesday, as NEC beat Excelsior 1-0.
Dutch club FC Twente have signed teenage striker Thomas Agyepong from Manchester City on loan.
Brentford have confirmed the signing of FC Twente defender Andreas Bjelland.
AZ claim a Europa League place at the expense of Feyenoord, who were consigned to the play-offs for a place in Europe.
AZ Alkmaar remain in contention to clinch a Europa League berth from the Eredivisie after a 2-0 win at FC Twente.
After the title was taken away from them on Saturday, Ajax were held by struggling NAC Breda at home on Sunday.
Feyenoord moved a step closer to qualifying for the Europa League after a 2-2 draw at Willem II Tilburg in the Eredivisie.
Former Eredivisie champions FC Twente have been docked three points for the second time this year.
Five-star PSV close in on Dutch title after comprehensive victory at FC Twente, while Heracles grab dramatic late win
PSV Eindhoven suffered a bump on the road to a probable Eredivisie title as they lost 2-1 at Feyenoord on Sunday.
Cash-strapped Twente Enschede returned to winning ways in the Eredivisie on Saturday with a 2-0 win over PEC Zwolle.
FC Twente recovered from 2-0 down to draw 2-2 at Willem II as both teams saw their fading European hopes take another hit.
Eridivisie side FC Twente have been deducted three points by the Dutch FA for failing to meet financial targets.
AZ Alkmaar had to overcame blustery conditions to beat Willem II 2-0 to reclaim third place in the Eredivisie on Saturday.
Ricardo Kishna struck twice as Ajax beat Twente 4-2 in the Eredivisie to cut PSV's Eredivisie lead back to 12 points.
Stefan Nijland scored in each half as PEC Zwolle moved up to third with a thumping 4-0 win at bottom side Dordrecht.