Davy Klaassen scored twice as Ajax Amsterdam trounced SC Cambuur 5-1 to extend their lead at the top of the Eredivisie.
Heracles missed the chance to close the gap on Eredivisie leaders Ajax as they conceded a 90th-minute equaliser at PEC Zwolle.
Feyenoord moved up to second in the Eredivisie with a 2-0 victory over PEC Zwolle while FC Twente ended their winless start.
Heracles Almelo moved to the top of the Dutch league with a 2-1 win over champions PSV Eindhoven at the Polman Stadion on Saturday.
Ajax's Anwar El Ghazi scored twice in a 4-0 win over ADO Den Haag that took them clear at the top of the Dutch league on Sunday.
There were wins for Ajax and Feyenoord in the Eredivisie on Sunday, while FC Twente slipped to defeat.
Michael de Leeuw rescued a point for Groningen in a 1-1 draw with Twente in the Eredivisie on Wednesday, as NEC beat Excelsior 1-0.
AZ claim a Europa League place at the expense of Feyenoord, who were consigned to the play-offs for a place in Europe.
NAC Breda face a relegation play-off, while Manchester United-bound Memphis Depay scored for PSV.
AZ Alkmaar remain in contention to clinch a Europa League berth from the Eredivisie after a 2-0 win at FC Twente.
After the title was taken away from them on Saturday, Ajax were held by struggling NAC Breda at home on Sunday.
PSV Eidenhoven moved to within touching distance of a first Eredivisie title in seven years with a 3-1 victory over PEC Zwolle.
Five-star PSV close in on Dutch title after comprehensive victory at FC Twente, while Heracles grab dramatic late win
PSV Eindhoven suffered a bump on the road to a probable Eredivisie title as they lost 2-1 at Feyenoord on Sunday.
Cash-strapped Twente Enschede returned to winning ways in the Eredivisie on Saturday with a 2-0 win over PEC Zwolle.
AZ Alkmaar had to overcame blustery conditions to beat Willem II 2-0 to reclaim third place in the Eredivisie on Saturday.
Ricardo Kishna struck twice as Ajax beat Twente 4-2 in the Eredivisie to cut PSV's Eredivisie lead back to 12 points.
Stefan Nijland scored in each half as PEC Zwolle moved up to third with a thumping 4-0 win at bottom side Dordrecht.
Ajax lost 1-0 at Vitesse Arnhem on Sunday to fall further behind PSV in the Eredivisie title race.
Eredivisie leaders PSV Eindhoven made it six wins in a row as they beat Cambuur 2-1 on Saturday evening.