AZ claim a Europa League place at the expense of Feyenoord, who were consigned to the play-offs for a place in Europe.
NAC Breda face a relegation play-off, while Manchester United-bound Memphis Depay scored for PSV.
AZ Alkmaar remain in contention to clinch a Europa League berth from the Eredivisie after a 2-0 win at FC Twente.
After the title was taken away from them on Saturday, Ajax were held by struggling NAC Breda at home on Sunday.
PSV Eidenhoven moved to within touching distance of a first Eredivisie title in seven years with a 3-1 victory over PEC Zwolle.
Five-star PSV close in on Dutch title after comprehensive victory at FC Twente, while Heracles grab dramatic late win
PSV Eindhoven suffered a bump on the road to a probable Eredivisie title as they lost 2-1 at Feyenoord on Sunday.
Cash-strapped Twente Enschede returned to winning ways in the Eredivisie on Saturday with a 2-0 win over PEC Zwolle.
AZ Alkmaar had to overcame blustery conditions to beat Willem II 2-0 to reclaim third place in the Eredivisie on Saturday.
Ricardo Kishna struck twice as Ajax beat Twente 4-2 in the Eredivisie to cut PSV's Eredivisie lead back to 12 points.
Stefan Nijland scored in each half as PEC Zwolle moved up to third with a thumping 4-0 win at bottom side Dordrecht.
Ajax lost 1-0 at Vitesse Arnhem on Sunday to fall further behind PSV in the Eredivisie title race.
Eredivisie leaders PSV Eindhoven made it six wins in a row as they beat Cambuur 2-1 on Saturday evening.
PSV Eindhoven re-established their four-point lead at the top of the Eredivisie after edging to a 1-0 win at Vitesse.
Ahead of Ajax v Feyenoord, we take a closer look at the Eredivisie title race.
PEC Zwolle moved up to fifth in the Eredivisie as they beat ADO Den Haag 3-1 and FC Twente drew 2-2 against Vitesse.
Ajax were held to a 1-1 draw at ADO Den Haag in the Eredivisie on Sunday, while FC Twente lost at home to FC Groningen.
PSV Eindhoven reasserted their authority with a 3-0 victory at Go Ahead Eagles on Saturday, while PEC Zwolle recorded a 6-1 win.
Eredivisie leaders PSV Eindhoven could only draw at FC Groningen on Sunday, while FC Twente beat PEC Zwolle to go third.
PEC Zwolle claimed a 2-0 win over FC Groningen in the Eredivisie on Saturday, while ADO Den Haag beat Willem II 3-2.