Luuk de Jond rescued a point for champions PSV, while their were wins for Heracles and Roda JC.
Feyenoord and Roda JC secured opening day victories in the Eredivisie.
AZ claim a Europa League place at the expense of Feyenoord, who were consigned to the play-offs for a place in Europe.
NAC Breda face a relegation play-off, while Manchester United-bound Memphis Depay scored for PSV.
PSV came from behind to extend their lead at the top of the Eredivisie standings, while there were wins for Heracles and Utrecht
After the title was taken away from them on Saturday, Ajax were held by struggling NAC Breda at home on Sunday.
Champions Ajax delayed PSV's impending Eredivisie title win for another week as they won 2-0 away at Heracles Almelo.
Five-star PSV close in on Dutch title after comprehensive victory at FC Twente, while Heracles grab dramatic late win
Markus Henriksen netted a late winner as AZ strengthened their grip on fourth place with a 2-1 win over Cambuur Leeuwarden.
Defender Nicolas Isimat-Mirin scored a rare goal to hand leaders PSV a nervy 2-1 home win over Groningen.
AZ Alkmaar had to overcame blustery conditions to beat Willem II 2-0 to reclaim third place in the Eredivisie on Saturday.
Feyenoord slipped 20 points behind leaders PSV in Eredivisie after a 2-0 defeat at lowly Heracles on Saturday.
AZ Alkmaar inflicted a second league defeat in four days upon Ajax as they registered a 1-0 win at the Amsterdam ArenA.
Ajax lost 1-0 at Vitesse Arnhem on Sunday to fall further behind PSV in the Eredivisie title race.
Feyenoord beat FC Twente to strengthen their hold of third place in the Eredivisie on Sunday, while Heerenveen won at Utrecht.
The first half of the Eredivisie season concluded with wins for Ajax and Feyenoord, but with PSV hold a four-point lead.
PEC Zwolle moved up to fifth in the Eredivisie as they beat ADO Den Haag 3-1 and FC Twente drew 2-2 against Vitesse.
FC Utrecht condemned struggling NAC Breda to a fourth consecutive Eredivisie defeat with a 5-1 thrashing on Saturday.
Eredivisie leaders PSV Eindhoven could only draw at FC Groningen on Sunday, while FC Twente beat PEC Zwolle to go third.
PSV Eindhoven reasserted their authority with a 3-0 victory at Go Ahead Eagles on Saturday, while PEC Zwolle recorded a 6-1 win.