Odion Ighalo continued his fine pre-season form as Watford ended their tour of Germany with a 2-0 victory over Paderborn.
Schalke have appointed former Paderborn boss Andre Breitenreiter as their new head coach.
Stuttgart came from behind to beat Paderborn 2-1 and secure their place in the Bundesliga next season.
Liverpool give U21s more game time than Premier League rivals but top flight lags behind Europe.
A last-gasp own-goal broke Paderborn hearts as they slumped to a 1-0 defeat at Schalke.
Wolfsburg regained second spot from Borussia Monchengladbach and left Paderborn inside the bottom two with a 3-1 win.
Bas Dost scored twice as Wolfsburg secured a Champions League spot, while Cologne guaranteed survival.
Paderborn came from behind to move out of the relegation zone and above their hosts Freiburg with a 2-1 win
Paderborn threw away a two-goal lead in their 2-2 Bundesliga draw against Werder Bremen.
Borussia Dortmund's first game after Jurgen Klopp announced his summer exit ended in a 3-0 win over Paderborn.
Paderborn picked up a crucial three points in their battle to avoid relegation after beating Augsburg 2-1.
Schalke's hopes of a top-four finish receded further after a goalless draw at Augsburg on Sunday.
Hertha Berlin took a potentially decisive step away from the Bundesliga's relegation zone with a 2-0 win over Paderborn.
Paderborn slipped into the bottom two of the Bundesliga after being held to a goalless draw at home by 10-man Hoffenheim on Saturday.
Augsburg's hopes of playing in Europe next season suffered a setback as they were beaten 2-0 at home by Mainz.
Eintracht Frankfurt got back to winning ways by dishing out a 4-0 win over Paderborn.
Bayer Leverkusen rose to fourth in the Bundesliga thanks to a 3-0 win at Paderborn, although they were made to work hard for all three points by the league strugglers.
Borussia Monchengladbach strengthened their grip on third place in the Bundesliga with a 2-0 victory over Paderborn.
Bayern Munich move 11 points clear of Wolfsburg at the top of the Bundesliga thanks to a 6-0 win at Paderborn.
Paderborn came back to beat Hannover 2-1 on Sunday to break their 10-match winless streak and climb out of the drop zone.