Serie A champions Juventus saw their 47-match unbeaten home league record come to an end against Udinese.
Palermo have signed Swedish international midfielder Oscar Hiljemark from PSV Eindhoven for an undisclosed fee.
Charlton have signed Denmark international striker Simon Makienok on a season-long loan from Palermo.
Rafael Benitez failed to deliver Champions League football to Napoli as his final act before leaving ended in a 4-2 loss to Lazio.
Andrea Belotti's last-gasp goal spoiled Roma's end-of-season party but they still finish second despite a 2-1 defeat.
Fiorentina qualified for the Europa League while Stephan El Shaarawy scored his first goal in seven months for AC Milan.
Liverpool give U21s more game time than Premier League rivals but top flight lags behind Europe.
Fiorentina qualified for the Europa League by holding Palermo at bay to win 3-2 at the Stadio Renzo Barbera.
Cagliari lost 1-0 at home to Palermo to suffer relegation and have their 11-year run in Serie A come to a painful end.
Napoli's hopes of Champions League qualification suffered a setback as they drew 2-2 at rock-bottom Parma in Serie A on Sunday.
Ten-man Atalanta boosted their Serie A survival hopes with a 3-2 triumph at Palermo on Sunday afternoon.
Paulo Dybala's future will be decided within the next two weeks, says Palermo chief Maurizio Zamparini.
Sassuolo and Palermo shared the spoils in a 0-0 draw on Saturday evening.
Torino kept up their pursuit of a place in Europe next season with a 2-2 draw at Palermo on Wednesday night.
Antonio Nocerino scored a first-half penalty to hand bottom-side Parma a 1-0 home triumph over Palermo.
Chelsea have bid for Palermo's Paulo Dybala but Juventus are leading the race to sign him, according to his intermediary.
Palermo's long wait for a second Serie A away win of the season came to an end with a 3-1 triumph at Udinese on Sunday.
AC Milan picked up their first win away from home since mid-October, and only their third of the season, by beating Palermo 2-1 at the Stadio Renzo Barbera.
Juventus closed in on a fourth straight Serie A title after a 2-0 victory over Empoli.