Crotone beat Lazio 3-1 on the final day to ensure survival, as Empoli went down after losing at already-relegated Palermo.
Napoli took advantage of Roma's derby defeat to close to within one point of second place in Serie A with victory over Inter Milan.
Juventus took a giant leap towards securing an historic sixth consecutive Serie A title by thrashing hapless Genoa 4-0 in Turin.
Juve extended their lead at the top of Serie A after beating Pescara 2-0 to strengthen their grip on a sixth straight Scudetto title.
Juventus' Gonzalo Higuain failed to score on his long-awaited return to Napoli as the game ended 1-1, while Crotone beat Chievo.
Chelsea loanee Juan Cuadrado was the hero for Juventus on a busy day of Serie A action, with Roma and Napoli also victorious.
A round-up of all the top transfer rumours across Europe, including reports Real Madrid want Kasper Schmeichel.
Juventus now lead Serie A by eight points after drawing 1-1 at Udinese on Sunday, while Lazio and Inter Milan both claimed away wins.
Roma closed the gap on Serie A leaders Juventus to seven points with a 3-1 win away to Inter Milan at San Siro.
Paulo Dybala scored twice as Juventus opened up a 10-point lead at the top of Serie A with a thumping 4-1 win against Palermo.
Gonzalo Higuain scored twice as Juventus preserved their seven-point lead in Serie A with a 2-0 victory at 10-man Cagliari.
Juan Cuadrado's thunderbolt gave Juventus 1-0 home win over Inter Milan on Sunday, as Sampdoria beat AC Milan and Lazio hit six.
Gonzalo Higuain reached 15 goals for the Serie A season as Juventus reinforced their position as leaders with a 2-0 win over Sassuolo.
Paulo Dybala and Gonzalo Higuain scored as Serie A leaders Juventus beat fourth-placed Lazio 2-0 on Sunday.
Roma bounced back from their Serie A defeat to Juventus at the weekend by coming from behind to beat Chievo 3-1.
A rare goal from Kevin Strootman helped Roma reclaim second place in the Serie A table as they beat derby rivals Lazio 2-0 on Sunday.
Frank de Boer's future as Inter Milan head coach is under serious threat after a 2-1 defeat to Atalanta in Bergamo on Sunday.
Juventus needed an unfortunate own goal from Edoardo Goldaniga to squeeze past Palermo while Napoli beat Chievo.
Mauro Icardi inspired a superb comeback win for Inter as they beat Juventus 2-1 on Sunday, while Roma lost at Fiorentina.
Gonzalo Higuain starred for Juventus with two goals as they beat Sassuolo 3-1 in Serie A on Saturday, as Napoli won 3-0 at Palermo.