Michiel Kramer scored a hat-trick as Feyenoord won the Rotterdam derby 4-2 at Excelsior to move level with leaders Ajax,
Davy Klaassen scored twice as Ajax Amsterdam trounced SC Cambuur 5-1 to extend their lead at the top of the Eredivisie.
Eredivisie leaders Ajax hammered Roda JC 6-0 to open up a three-point gap at the top of the table.
PSV Eindhoven and Heracles maintained their pressure on the Eredivisie's top two with late away wins on Saturday.
Alireza Jahanbakhsh was NEC Nijmegen's hero with a two-goal haul helping to beat Ajax, condemning Roda JC to the drop.
Ajax clinched their fourth successive Eredivisie title with a 1-1 draw against Heracles Almelo on Sunday.
Roda JC's place in the Eredivisie's bottom three was confirmed on Saturday as they fell to a 3-0 defeat to FC Twente.
Ajax still have work to do to wrap up their Eredivisie title defence following a 1-1 draw at Vitesse.
Ajax returned to winning ways with a 3-0 home victory over FC Twente while Feyenoord thumped Go Ahead Eagles 5-0.
PSV moved to second place in the Eredivisie after they beat Roda JC and Vitesse Arnhem were beaten by Groningen.
Vitesse Arnhem lost ground in the Eredivisie title race on Saturday as they went down 2-1 at home to PSV Eindhoven.
Vitesse Arnhem kept the pressure up Ajax with a win at NAC Breda in the Eredivisie, while PSV Eindhoven beat FC Utrecht.
Vitesse moved into second place in the Eredivisie table following a 3-0 victory over bottom side Roda JC on Saturday.
PSV Eindhoven claimed a 2-0 win at struggling NEC Nijmegen, while Heerenveen played out a 0-0 draw at NAC Breda.
FC Twente kept the heat up on Eredivisie leaders Ajax with a 2-0 home win over 10-man Vitesse Arnhem.
PSV Eindhoven beat second-placed FC Twente in a five-goal thriller, while Feyenoord hammered NEC Nijmegen.
Vitesse Arnhem's bid to go top of the Eredivisie on Tuesday night was wrecked as AZ Alkmaar claimed a 2-0 victory.
Alfred Finnbogason continued his prolific form this season as Heerenveen with a 3-0 win over ADO Den Haag.
Feyenoord suffered a setback in their bid to breach the Eredivisie's top three after going down 3-2 at ADO Den Haag.
Roda JC's Krisztian Nemeth has been banned for five matches after his sending-off in Tuesday's defeat to AZ Alkmaar.