Red-hot Fiorentina replaced Inter Milan as Serie A leaders by cruising to a 3-0 home victory over Atalanta on Sunday.
Juventus could only draw 1-1 at home to Frosinone in Serie A on Wednesday, as leaders Inter Milan beat Hellas Verona 1-0.
A Gonzalo Higuain-inspired Napoli ran riot against Lazio while there were also wins for Inter Milan and Fiorentina.
Eder set the ball rolling as Sampdoria maintained their unbeaten start to the season with a 2-0 victory over Bologna.
Serie A champions Juventus saw their 47-match unbeaten home league record come to an end against Udinese.
Manchester United have signed Argentina international goalkeeper Sergio Romero on a three-year contract.
Turkish Super League club Antalyaspor are confident of signing Cameroon forward Samuel Eto'o from Sampdoria this summer.
Former Sampdoria coach Sinisa Mihajlovic insists he will be the new coach of AC Milan "within two weeks".
Sinisa Mihajlovic is close to being announced as the new head coach of struggling AC Milan, according to reports in Italy.
Sinisa Mihajlovic has stepped down as coach of Sampdoria, amid speculation he will replace Rafael Benitez at Napoli.
Fiorentina qualified for the Europa League while Stephan El Shaarawy scored his first goal in seven months for AC Milan.
Liverpool give U21s more game time than Premier League rivals but top flight lags behind Europe.
Substitute Samuel Eto'o struck a last-gasp equaliser at Empoli but Sampdoria's European hopes were ended.
Lazio are potentially just one win away from booking their place in the Champions League after beating Sampdoria 1-0.
Inter Milan are in danger of missing out on a European place after goalkeeper Samir Handanovic gifted champions Juventus a 2-1 victory.
Napoli's hopes of Champions League qualification suffered a setback as they drew 2-2 at rock-bottom Parma in Serie A on Sunday.
Roberto Soriano struck twice as Sampdoria halted a six-match winless run with a 4-1 triumph at Udinese.
Juventus wrapped up a fourth straight Serie A title on Saturday evening thanks to a 1-0 win at Sampdoria.
Sampdoria were held to a 1-1 draw at home by Hellas Verona in Serie A on Wednesday night.
Juventus will have to wait another week to secure their status as Serie A champions after falling to a 2-1 defeat at Torino.