Spain forwards David Silva and Alvaro Morata have withdrawn from the squad to face Ukraine on Monday through injury.
Spain made it through to Euro 2016 with a win over Luxembourg, but there was an injury worry for Manchester City's David Silva.
From a Portugal playmaker to an Arsenal youth product, we pick five exciting players to watch on Sky during the qualifiers.
Watch Santi Cazorla's double as Spain beat Luxembourg 4-0 to reach Euro 2016.
A look ahead to Friday's European Qualifiers as Spain can book their place at Euro 2016 with a win over Luxembourg.
Spain coach Vicente del Bosque has left Chelsea striker Diego Costa out of his squad for their upcoming European Qualifiers.
Former Real Madrid and Spain midfielder Ignacio Zoco has died at the age of 76.
David de Gea says he is "enjoying football" and is ready to return for Manchester United after starting for Spain.
David de Gea played his first competitive match since May as Spain beat Macedonia, while Austria qualified in style for Euro 2016.
Spain still have not replaced David Villa as their striker issues continue with Diego Costa, says Terry Gibson
Sergio Ramos wants Spain fans to stop booing Gerard Pique, believing the defender's political views can't be changed.
Spain coach Vicente del Bosque has backed Diego Costa, despite seeing the Chelsea forward draw another blank in front of goal.
Spain have revealed their friendly against England in November will be played in Alicante.
In Saturday's European Qualifiers, Spain saw off Slovakia 2-0, Switzerland fought back to beat Slovenia, and Russia overcame Sweden.
Defending champions Spain can take a big step towards qualifying for Euro 2016 while Austria could book their spot at the finals.
Spain coach Vicente del Bosque has revealed he considered calling up out-of-favour Victor Valdes in his latest selection.
Chelsea winger Pedro has criticised Louis van Gaal for his treatment of Manchester United goalkeeper Victor Valdes.
The startling statistics that highlight Cesc Fabregas's deteriorating form for Chelsea.
David de Gea has been named in Manchester United's squad for the Champions League this season.
Big-money transfer signings Memphis Depay, Georginio Wijnaldum and Kevin De Bruyne are all in action on Sky Sports.