Inter Milan suffered a surprise 2-0 defeat to Chievo on the opening weekend of Serie A while Napoli also struggled.
Former Italy striker Luca Toni has announced his retirement from football after a career spanning three decades.
Juventus celebrated winning the Serie A title for the fifth year in a row by beating relegation-threatened Carpi 2-0.
Hellas Verona beat AC Milan but Carpi's 1-0 victory over Empoli confirmed relegation from Serie A for Luigi Delneri's side.
Paulo Dybala scored twice as Juventus thrashed Lazio 3-0 to take what could prove to be a decisive lead in Serie A.
Juventus moved a step closer to a fifth straight Serie A title after pulling nine points clear with a 4-0 win over Palermo.
Napoli are back within six points of Serie A leaders Juventus after beating bottom club Hellas Verona 3-0 on Sunday.
Hellas Verona boosted their slim Serie A survival hopes with a 1-0 victory at Bologna on Monday evening
Goalkeeper Gianluigi Buffon added another record to his decorated career during Juventus' 4-1 win over local rivals Torino.
Gonzalo Higuain's penalty saw Napoli squeeze past Palermo 1-0 and maintain their pursuit of the Serie A title.
Francesco Totti made his 600th Serie A appearance as Roma moved up to second spot with a 3-0 win over Chievo.
Napoli kept pace with fellow title-chasers Juventus after coming from behind to beat Chievo Verona 3-1 at the Stadio San Paolo.
Mauro Icardi scored against his former club as Inter Milan moved up to fourth in Serie A with a 3-1 victory over Sampdoria at the San Siro.
Gonzalo Higuain scored a late penalty to give Napoli a 1-0 victory over Carpi on Sunday and keep them top of Serie A.
Crystal Palace are bottom of the Europe-wide form table - and only one Premier League team makes the top 10.
Ten-man Juventus needed an own goal from Genoa defender Sebastian De Maio to maintain their pursuit of Serie A leaders Napoli.
Juventus blew Udinese away 4-0 to record their 10th consecutive Serie A victory while AC Milan beat Fiorentina.
Domenico Berardi converted a penalty in injury time on Sunday to give Sassuolo a shock 1-0 win away at Inter Milan.
Juventus stormed back into the title race by beating Hellas Verona 3-0 to register an eighth straight Serie A win.
Former AC Milan and Roma winger Urby Emanuelson has joined Hellas Verona on a free transfer.