Crystal Palace are bottom of the Europe-wide form table - and only one Premier League team makes the top 10.
Athletic Bilbao moved up to fifth in La Liga with a narrow 1-0 win at Getafe on Saturday.
Villarreal extended their unbeaten run in La Liga to seven matches following a 2-2 draw with Espanyol, while Granada beat Getafe.
Munir El Haddadi scored both of Barcelona's goals as they recorded a 2-0 win at Espanyol to cruise through in the Copa del Rey.
Atletico Madrid returned to the top of La Liga with a 2-0 victory at Celta Vigo, their 18th clean sheet of the season in all competitions.
Nottingham Forest boss Dougie Freedman has had his squad boosted by the signing of defender Bojan Jokic on loan.
Athletic Bilbao fought back from a two-goal deficit to beat Villarreal, while Atletico Madrid were held by Rayo Vallecano.
Nottingham Forest are closing in on a deal to bring Slovenia international Bojan Jokic to the City Ground on loan.
Bruno Soriano's stoppage-time penalty secured a 2-1 win for Villarreal at Deportivo to strengthen their hold on fourth.
Gary Neville is still looking for his first La Liga win in charge of Valencia after his side went down 1-0 at Villarreal.
Live updates as Gary Neville continues his hunt for a first La Liga win. Watch live on SS1 from 2.55pm.
Manchester United will face Midtjylland in the last 32 of the Europa League, while Liverpool take on Augsburg and Spurs face Fiorentina.
Real Madrid suffered their third league loss of the Primera Division season after going down 1-0 at Villarreal on Sunday.
Reaction as Real Madrid lose further ground in La Liga with defeat at Villarreal. Watch live on Sky Sports 1.
Roberto Soldado was Villarreal's goalscoring hero as the Yellow Submarine beat Real Madrid 1-0 in La Liga on Sunday.
Besiktas and Ajax were eliminated from the Europa League while Borussia Dortmund finished second in their group.
Villarreal moved up to fifth in La Liga thanks to Cedric Bakambu's second-half double in their 2-1 win over Rayo Vallecano on Sunday.
Segunda Division strugglers Huesca upset Villarreal 3-2 in the first leg of their Copa del Rey last-32 tie on Thursday.
Real Madrid boss Rafa Benitez remains positive about the La Liga title race despite defeat at Villarreal.
Sevilla climbed into the top half of the La Liga table after beating nine-man Valencia 1-0 on Sunday.