Last Updated: 16/03/14 5:52pm
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Arsenal are up to third, four adrift of Chelsea with a game in hand and only behind Liverpool on goal difference. They are also now nine ahead of Tottenham, whose hopes of a top four finish are fading rapidly.
Free-kick to Arsenal outside their own box. That will probably be that. Soldado booked for going in late on Koscielny.
A third defensive switch for Wenger, with Thomas Vermaelen coming on from Oxlade-Chamberlain, who is reported to have a tight calf.
Final change for Spurs, as Roberto Soldado comes on for Eriksen. A decision which gets a mixed reaction from the home fans.
Good hands from Szczesny as he gather's Townsend's cross, but his quick ball out to Oxlade-Chamberlain puts his team-mate under pressure and the Gunners are lucky to earn a goal-kick.
Flamini goes into the book for going through Eriksen as he looked to turn the Arsenal man near the halfway line.
Tremendous save from Lloris, adjusting his feet quickly and reaching down to his right to stop Mertesacker's effort from inside the box.
Nacho Monreal comes on for Podolski, who looked to be blowing hard moments earlier. He will play in front of Gibbs to shore up that left-hand side.
Arteta's ball towards the far post finds Koscielny tussling with Vertonghen and the Spurs man is fortunate not to be penalised as he had an arm around his opponent.
Vertonghen is the latest player to go into the book as he slides in on Cazorla and sends the Arsenal man tumbling.
Poor from Spurs, as they gift Arsenal possession from a throw deep in the Gunners' half, but Podolski does not have the legs to get onto the end of Cazorla's pass.
Just two crosses from Arsenal so far today, while Tottenham have put the ball into their opponents' box 29 times.
And a change for Arsenal too, with goalscorer Rosicky, who doesn't look massively impressed, replaced by the more defensive-minded Mathieu Flamini.
The second attempt is better, but is fisted away by Szczesny, before Naughton returns the ball into the area and the Arsenal keeper gathers the resulting header.
Koscielny has to be alert to cut out Townsend's cross to the near post with Adebayor ready to pounce, before Eriksen's corner is way too deep, and he's lucky to get a second chance.
Adebayor drives a shot against Arteta's backside from outside the box, but then races into the area and is only narrowly wide with a glancing header from Bentaleb's ball into the back post.
Spurs go back on the attack, but first Adebayor's cross is too long and then Chadli's attempt with the second ball is simple for Szczesny.
Rare spell of pressure and possession for Arsenal, having been on the back foot for much of the second half.
Townsend goes to ground on the edge of the area as he attempts a one-two with Adebayor, but Dean is again - correctly- not interested.
Nice play from Cazorla to find Oxlade-Chamberlain bursting into Spurs territory. He finds Giroud, who attempts to return the favour but gets his weight of the pass wrong.
Another key interception from Kaboul, as he gets his head to the resulting corner, taking the flight of the ball away from Giroud who was winding up a volley.
Cazorla's pass almost sets Podolski away, but Kaboul comes over to deny the German with a fine sliding challenge.
Good ball in from Naughton, which flicks off the head of Bentaleb, arguably taking it away from Adebayor who was poised behind his team-mate.
Tottenham's fans have found their voices and are urging their side on after a breathless start to the second half.
And we're straight back up the other end of the field, with Adebayor feeding Townsend, whose low cross goes straight past Chadli who cannot get a telling touch to find the net.
Poor pass out of defence from Vertonghen sells Rose short and allows Rosicky to charge towards goal, only to be crowded out.
Superb start to the half from Spurs, they've pushed Arsenal right onto the back foot and should have levelled after those two Szczesny blunders.
Seconds later, Szczesny is again found wanting, flapping horribly at another cross from the right and leaving Chadli with a glorious chance to level. The Spurs man takes too many touches and Koscielny is able to block in front of the gaping goal.
Naughton swings a ball in towards Adebayor, which Szczesny fails to gather on the edge of his own box, but Sagna intervenes before Chadli can take advantage.
Giroud sweeps a pass out to Podolski down the left. The German attempts to take on Kyle Naughton, but the Spurs man does well and is able to clear.
Wenger arrives slightly late for the second period and looks none-too impressed with the efforts of his side so far, despite their lead.
It's been a very open half, which was kick-started in spectacular fashion by Rosicky's opener after 72 seconds. Oxlade-Chamberlain missed a glorious chance to make it 2-0, but Spurs have enjoyed the majority of the ball, without really troubling Arsenal keeper Szczesny.
Rose cuts into the box and goes to ground under a challenge from Sagna, which looked clumsy, but referee Dean simply shakes his head.
Good ball from Rosicky puts Podolski in against Kaboul, but the defender does well on this occasion to hold up the Arsenal man.
Play immediately switches to the other end, with Rosicky leaving Rose on the floor and cutting the ball back for Oxlade-Chamberlain, who leans back horribly and gets under the ball to fire it way over Lloris' bar.
Chance for Chadli as he breaks towards the Arsenal box, only to get his shot all wrong and drag it wide of the target.
Good strength again from Oxlade-Chamberlain as he holds off his man in the centre and then tries a pass out to Rosicky down the right, only to over-cook the pass.
Podolski thinks he has released Giroud through the middle, but the flag goes up very late to stop the French striker in his tracks.
Lovely reverse pass from Eriksen looks set to reach an onrushing Rose, but Sagna times his tackle to perfection on the edge of the area.
Another chance for Arsenal as Podolski gets in behind a dozing Kaboul and unleashes a shot which whizzes beyond Lloris but into the side netting.
Oxlade-Chamberlain powers away from Sandro on the right and then attempts to play a pass into Giroud in the centre, but Spurs are able to cut it out and clear.
Chadli goes into the book for a clumsy challenge on Rosicky, while Sandro is lucky not to join him for remonstrating with referee Dean and placing his hands on the official.
Good strength from Sandro to seize possession in the middle and feed Adebayor, but his attempted pass to Townsend is too strong.
Rose swings a diagonal ball into the box which Chadli heads down, but Bentaleb cannot gather and Arsenal clear.
Free-kick for Spurs in an interesting position just outside the right corner of the Arsenal box after Podolski brings down Naughton.
Close for Spurs! Naughton and Lennon combine well on the right, with the former's cross to the near post flicked towards goal by Adebayor under pressure from Mertesacker, but it goes across the face and narrowly wide.
Arsenal hit Spurs on the break again, with Rosicky feeding Podolski down the left. He cuts the ball back across the box and Oxlade-Chamberlain sees his shot deflected behind for a corner, which Mertesacker can only flick into Lloris' gloves.
Another stunning pass from deep from Sandro picks out Adebayor in behind the Arsenal defence. He attempts an audacious overhead attempt which fails to find the target and picks himself up to find that the flag had gone up.
Eriksen's second delivery is poor and Arsenal can clear their lines, albeit with a hopeful appeal for handball outside the area which is ignored.
Sagna sends Rose cartwheeling into the air with a heavy challenge, but referee Dean decides a yellow card will suffice.
After 20 minutes of the game, only five per cent of the action has been in Tottenham's final third. Yet they trail 1-0 after Rosicky's early rocket and could have been 2-0 down had Oxlade-Chamberlain executed his attempted chip.
Good play from Townsend to pick up the ball, burst into the box and drill a cross-shot across the face. Spurs regain possession and Eriksen sees two shots blocked in quick succession.
Rose works a yard of space against Sagna and swings over another cross, but the ball has far too much pace on it and flies all the way across the box and out for a throw on the far side of the field.
More touchline histrionics from Sherwood, as he takes off his body-warmer (or gilet, if you prefer) and hurls it to the ground in frustration.
From the sublime to the ridiculous from Oxlade-Chamberlain. The England man eases away from Bentaleb to find himself one-on-one with Lloris, only for his attempted lob to go horribly wrong and miss the target by some distance.
Some neat play from Chadli to get away from Arteta and then run at the Arsenal defence ends when he goes to ground just outside the box, but referee Dean is not interested and play continues.
Neat play from Giroud to keep possession in the centre circle before Arteta's ball over the top finds Podolski breaking in behind the Spurs defence, only for the flag to go up for offside. Tight call.
Eriksen tries to play a reverse pass into the Arsenal box on the left, but Rose had failed to read his intentions and the ball rolls through to Szczesny after a neat step-over from referee Dean.
Adebayor and Townsend attempt to combine down the right flank, but only succeed in running into each other...
Decent cross in from the left by Rose, but Koscielny is able to clear his lines with Adebayor lurking.
Giroud is down and in need of some treatment after taking a high boot in the face from Vertonghen, but is OK to continue.
Eriksen drifts a free-kick in towards the far post of the Arsenal box, where it is headed back into the danger zone, only for Adebayor to be penalised for high feet as he attempts an ambitious overhead kick.
A lovely flighted ball over the top from Sandro looks to have found Adebayor in space behind the Arsenal defence, but the pass just eludes the big striker and drifts harmlessly out for a goalkick.
Perfect start for the visitors, taking the lead with just over 60 seconds on the clock with their very first attack of the game. That shifts the onus firmly onto Spurs to now break down Arsenal.
Stunning, stunning strike from Rosicky! He breaks from inside his own half and then exchanges passes with Oxlade-Chamberlain before unleashing a right-foot rocket which leaves Lloris grasping at thin air as it flies into the top corner.
Early touch out on the right flank for Adebayor, but he cannot get away from Gibbs, who puts it out for a throw.
Quick handshake between Wenger and Sherwood prior to kick-off. Let's hope the Spurs boss doesn't fall out with his counterpart after locking horns with Benfica's Jorge Jesus on Thursday night.
The pre-match formalities are complete, time for some final warm-ups and then the action will commence.
Here we go.... The players head out onto the pitch to be greeted by a wall of noise as White Hart Lane basks in the spring sunshine.
The two teams are in the tunnel at White Hart Lane ready to be lead out onto the field by referee Mike Dean.
Our colleagues at Sky Bet have Arsenal as the 5/4 favourites to win today, with Spurs available to back at 23/10 and the draw on offer at 12/5. There are a host of markets available on this clash, so head to www.skybet.com for all the latest odds.
Arsenal fan @CarlyFletch says: 'After the first result of the day a win is a must for Arsenal. Fancy us to win 2-1 in what is definitely a six-pointer.'
Arsenal are without injured midfielder Mesut Ozil, which means Tomas Rosicky comes into the starting XI for manager Arsene Wenger's 999th match in charge. England defender Kieran Gibbs returns at full-back after missing the midweek Champions League exit to Bayern Munich, so captain Thomas Vermaelen is on the bench again. Goalkeeper Wojciech Szczesny returns from his European suspension.
Sherwood has made four changes to his team from their midweek Europa League defeat at home to Benfica. Danny Rose, Nabil Bentaleb, winger Andros Townsend and Nacer Chadli all come in, while Emmanuel Adebayor has passed a fitness test to lead the line against his old club.
Chris Green writes: 'Tottenham were diabolical in midweek, but I see them bouncing back today if they can deliver the goods. Prediction: Tottenham 1-0 Arsenal, with Eriksen scoring the goal.'
Victory for Tottenham today would move them to within striking distance of Arsenal, although they have played a game more than the Gunners, and would be a much needed tonic after some poor results and performances for Sherwood's side.
Liverpool's victory has sent them back up to second in the table, four points adrift of Chelsea, but with a game in hand. Arsenal will join them on 62 points with a victory this afternoon, while opening up a nine-point cushion on their rivals in fifth.
The referee for today's clash is Mike Dean. He'll be hoping for a quieter afternoon than colleague Mark Clattenburg has just had at Old Trafford, where he awarded three penalties to Liverpool and sent off Manchester United's Nemanja Vidic as the visitors triumphed 3-0.
And @UNIIK_OFFICIAL writes: 'I'm in church as the match is being played, praying for a big win for @Arsenal .. I think 2-0 again on Walcott's 25th bday..'
But @andymayirou is another baffled by Tim Sherwood's team selection: 'Struggling to understand Sherwood's logic. Evidently picking a team rotated for Thursday when PL is much more important.'
Spurs fan Jack Stephens says: 'I for one am happy to see Bentaleb in for Paulino, I thought Paulino was shocking vs Benfica. 2-1 to Spurs! COYS!'
Opta stat No.4: Tottenham have kept just one clean sheet in their last 30 Premier League north London derbies (Feb 2009).
Opta stat No.3: Tottenham are seeking their 50th league win over the Gunners. Arsenal have won 63 and there have been 41 draws.
Opta stat No.2: Arsenal have won none of the last five Premier League north London derbies at White Hart Lane (W0 D2 L3) with all three defeats by a 2-1 scoreline.
Opta stat No.1: Only Liverpool v Newcastle (126) has seen more goals than Arsenal v Tottenham (125) in Premier League history.
And fellow Gunner Charlie Fazackerley adds: 'Spurs team looks weak, Bentaleb, Rose, Naughton and Chadli would get nowhere near this Arsenal team.'
Arsenal supporter Richard Paul also has a question mark over his team, but is much more confident: 'Not sure why Kallstrom's not playing.... thought he was fit? We can't underestimate Spurs, they will always be up for this match. Nonetheless, 2-0 to the Gunners, Giroud and Mertesaker.'
Spurs fan Matty Bevens has been in touch and is not happy with the team: 'Chadli for Lennon?? Bentaleb instead of Paulinho?? Not for me, I can see us getting smashed 0-3 Arsenal I reckon, thanks Tim.'
If you want to have your say on today's clash then you can drop me a line to email@example.com or via Twitter @skysportsrobp and I'll publish a selection of the best prior to kick-off.
Tottenham: Lloris; Naughton, Kaboul, Vertonghen, Rose; Sandro; Townsend, Bentaleb, Eriksen, Chadli; Adebayor. Subs: Friedel, Walker, Lennon, Paulinho, Sigurdsson, Kane, Soldado.
Arsenal: Szczesny, Sagna, Koscielny, Mertesacker, Gibbs, Arteta, Rosicky, Oxlade-Chamberlain, Podolski, Cazorla, Giroud. Subs: Fabianski, Monreal, Vermaelen, Jenkinson, Flamini, Gnabry Sanogo.
Don't forget today's clash is live on Sky Sports 1HD, but if you can't watch, then stay right here and I'll keep you right up to date with all the action.