Last Updated: 05/01/13 7:15pm
A dramatically late Van Persie equaliser rescues Manchester United from FA Cup elimination at West Ham in a 2-2 draw. Joe Cole had looked set to inspire the Hammers to victory in a fairytale win on his second debut having set up both headed goals for the excellent Collins either side of half-time to cancel out Cleverley's opener. However, substitute Van Persie stepped off the bench to score a wonderful equaliser in injury time before the final whistle to set up a replay at Old Trafford on 16th January. Stay with us for all the post-match reaction.
Corner to Man United and West Ham nerves are shredded. After a bit of pinball in the box, Valencia skies an effort over the crossbar.
West Ham are rocked and now Man United look like they fancy a winner. A Rafael cross goes across the face of goal.
Typical Man United. Giggs releases Van Persie down the inside right channel with a stunning cross-field pass. With a sublime first-touch, Van Persie controls the ball, runs clear of the defence and finishes through Jaaskelainen. It is a wonderful goal.
There is a scramble inside the Man United box. Noble heads a ball back across goal and Carlton Cole cannot quite toe-poke what would surely have been the winner when being beaten to the ball by the boot of De Gea.
It is all too congested for Man United on the edge of the West Ham box. The home side are sensing they can win this.
Jaaskelainen is taking his time over set-pieces as West Ham look to run down the clock. Man United are still not offering much.
It is all very edgy around Upton Park as West Ham fans anxiously wait for the final whistle. Their team are trying to make the game scrappy and are disrupting Man United.
Noble dinks the free-kick into the six-yard box and Man United clear to the edge of the box. But Collison following up balloons and 18-yard effort well over the crossbar.
Vidic's frustration is clear. He brings down Jarvis close to West Ham's left corner and then kicks the ball away in annoyance to earn a booking.
West Ham are getting good numbers in central areas and making it impossible for Man United to play through them. The home team are working incredibly hard.
Demel heads the first corner away for another set-piece. Man United take their second corner quickly and short. Buttner's cross is dangerous but Carlton Cole can head clear on the edge of the six-yard box.
Kagawa is a player Man United need to try and get into the game for the final 10 minutes. When he has the ball at his feet, he worries West Ham. The visitors win a corner.
The game has become very tight and nervy. West Ham are shutting up shop. But other than Welbeck's header, Man United have not looked like opening them up.
West Ham also make a change. A clearly tired Joe Cole goes off to a standing ovation and is replaced by Taylor.
Man United are completely dominating possession. Nolan, who was playing in support of Carlton Cole, is now dropping to the edge of his own penalty area.
Man United are now readying Giggs for what would be there final substitution. Can he inspire another comeback?
It looks like Joe Cole could be running out of steam and he was gesturing to the West Ham bench that he would like to come off before they instead replaced Diarra.
West Ham are now being forced to drop very deep. They appear to be planning to try and defend their lead. Buttner stands up a cross from the right and Welbeck heads over the crossbar.
Upton Park has gone a little quiet. West Ham fans will be wary of Man United's history of come backs and they could be in for a nervous final 20 minutes. Potts goes on a run forward but cannot keep the ball in play. Goal-kick to Man United.
Man United are playing the game on the edge of West Ham's penalty area but Cleverley gives away a goal-kick.
Van Persie is straight into the action and, from Buttner's corner, he heads wide at the near post following a darting run.
Corner to Man United. At the break in play, they make their changes. Scholes and Hernandez are the players to be replaced by Valencia and Van Persie.
Man United are going to make a double change and Van Persie and Valencia are going to be the men who come on.
Joe Cole has just made his way back on to the pitch after a brief spell off for what looked like a nose bleed.
Not for the first time this evening, Carlton Cole wins a header against the Man United defence. The striker has had a very good game.
Man United have always looked susceptible to crosses and when defending the ball in the air today. It has been a bit of a story of their season.
It is almost an exact copy of West Ham's equaliser. Joe Cole cuts in from the left and whips in a cross with his right foot. Collins has drifted off Vidic and again sends a glancing header past De Gea. What an influence from Joe Cole.
Man United move straight up the other end of the field and Tomkins has to defend bravely when throwing himself in the path of a Kagawa shot from inside the box.
It has been a bit of a low-key start to the second half. But Joe Cole keeps the ball in play and delivers a cross to the byline, which Carlton Cole heads on target and forces a diving save from De Gea.
The West Ham medical staff are on the field to treat Collison. It looks like he was winded in an accidental collision with Rafael.
Ferguson will be pleased with how his side are playing at the moment. They have regained the control of the contest.
Man United are dominating the opening minutes of the second half in a similar fashion to the start of match.
Smalling has room for a cross on the right but his delivery is poor. Welbeck then cannot quite control the ball in the six-yard box and it is a goal-kick to West Ham.
Nolan is doing a better job in getting close to Scholes when Man United have the ball than he was doing in the first half-an-hour.
West Ham this time build an attack down the right but De Gea comes off his line to catch a cross off the head of Tomkins.
The ball drops invitingly for Cleverley right on the edge of the box. But with two West Ham defenders closing him down, the midfielder smacks his shot over the crossbar.
A bit of a scrappy start to the second half. De Gea sends a long ball up field and Hernandez pushes Collins to give away a foul.
Carlton Cole keeps his balance in the penalty area after a coming together with Vidic but his low cross is behind Joe Cole and does not have the power to find Nolan.
Again Vaz Te goes for the spectacular. His shooting is again wayward in and around the penalty area as this time the effort goes high over the crossbar.
There is a break in play so that Vaz Te can seemingly sort out a problem with his boot. West Ham eventually take their throw-in. Ferguson again remonstrates with the fourth official about the break in play.
West Ham remain on the attack but Vaz Te is a little selfish when cutting in from the left and sending an ambitious long-ranger swerving well wide of the target. Allardyce is not impressed on the touchline.
West Ham win another free-kick on the right of the Man United penalty area. They have had a few of these and it is a chance to send the ball into the box. But it is headed clear by the first defender.
Carlton Cole has the ball at his feet after good control on his chest and turn. He took on Evans and won a throw-in.
Collison is booked for a blatant foul on Rafael. He lost the ball and knew Rafael could break so decided to take a yellow card to avoid Man United attacking. Gamesmanship.
Ferguson is having words with the fourth official after Welbeck was caught by a late challenge and play continued. Ferguson thought it was a foul.
Corner to West Ham on the right. Collison's delivery is towards the head of Carlton Cole but Man United clear and break. Welbeck darts down the right and forces a save from Jaaskelainen from a tight angle. Hernandez is not happy he did not get a pass to the back post.
Hernandez has his hands up in an apology to his team-mates after taking on a rare 30-yard effort and hitting it a long way over the crossbar.
Man United have lost their way a little bit. Smalling's pass down the right towards Rafael is a bit heavy and it rolls out for a goal-kick to West Ham.
Free-kick to West Ham wide on the right. Joe Cole sends the ball into the box but, competing with Smalling for the ball, Collins cannot get a decent connection and heads wide.
West Ham have shout for a penalty after Vidic goes over the top of Nolan when competing for a header. It looks like Nolan went down a little easily.
Joe Cole is clearly in the mood for this game. But he is breathing very heavily already. He has not had many starts in recent weeks.
West Ham are doing better at getting around Man United's midfielders and are giving the likes of Scholes less space in which to operate.
Man United never completely cleared the free-kick. Debutant Joe Cole puts his mark on the game by picking up the ball on the left and sending a curling, fast cross to the head of Collins, whose glancing header from inside the box gives De Gea no chance.
Another free-kick to West Ham. This time it is a bit deeper. Carlton Cole was fouled by Vidic. The Man United captain then makes up for his foul by heading clear the set-piece.
Joe Cole chips the free-kick to the back post and Vaz Te heads the ball from six yards but it is straight at De Gea.
Scholes goes in the book for a poor sliding tackle from behind on Collison. Free-kick to West Ham on the edge of the Man United box.
Man United make their dominance count. Hernandez squares the ball across the face of goal and Cleverley, in absolutely acres of space at the back post, finishes first time with a composed side-foot. Terrible defending from West Ham. The marking on Cleverley was non-existent.
Man United only half clear, though, and from Carlton Cole's knock on Nolan prods the ball at De Gea. But Nolan was offside.
Demel, attempting to atone for his earlier error, charges forward and wins West Ham a corner on the right. From the set-piece Collison's delivery is very poor.
Poor defending from Collins allowed Vidic the run and the header at the corner. West Ham will need to improve on that at set-pieces.
Free-kick to Man United around 30 yards from the West Ham goal. Scholes lobs the ball into a meaningless area but, with poor communication, Demel concedes a cheap corner.
West Ham look a threat when getting the ball into the area in the air from wide areas. Carlton Cole's presence is causing a few problems.
Welbeck has the ball in the back of the net after a layback from Hernandez. But Hernandez was offside when collecting Kagawa's initial pass.
Free-kick to West Ham inside their own half. But Collins launches it into the penalty area. It goes over the head of Carlton Cole and Nolan cannot quite get a touch to direct it on target. The ball bounces out for a goal-kick.
Scholes cannot be given this much room to pick his passes from deep in midfield. He again sprays the ball out to the right but Man United's attack breaks down.
West Ham are coming into the game. Vaz Te is tripped by Scholes but play continues and Collison sends a 25-yard effort over the crossbar. That could have been a booking for Scholes.
From the set-piece, Diarra's header has to be cleared off the line and then Vidic just prevents Carlton Cole from knocking in the rebound. That was a danger for Man United.
Potts wins West Ham a corner from Evans after Joe Cole did well to keep the ball alive on the left touchline.
Joe Cole has not seen much of the ball in the opening 10 minutes but then plays a pass to Carlton Cole before also giving possession to Diarra.
Scholes finds a good run down the right from Smalling and he sends a low cross along the six-yard box but it is just out of reach of the sliding Hernandez at the back post.
Apologies for the delay. We are having technical problems. Scholes finds a good run down the right from Smalling and he sends a low cross along the six-yard box but it is just out of reach of the sliding Hernandez at the back post.
It looks like Rafael is playing on right midfield in front of Smalling and Man United are pushing a lot of their attacks down that side.
De Gea has the ball for the first time so far in the match and it is comfortable for the Man United goalkeeper.
Sir Alex Ferguson's away team are making all the early play. They win a throw-in deep in West Ham territory and keep the ball on the edge of their hosts' box.
Man United move up field and Cleverley looks to slip in Hernandez but the ball rolls through to Jaaskelainen.
Man United keep the ball for the opening 60 seconds. West Ham are happy to drop off and let their visitors have the ball in their own half.
Jamie Warrior says: 'As a Red Devil, I am a bit worried today but hopefully we can just edge a very strong Irons side. My prediction is Man Utd 3-2 West Ham. Although I would like to see Joe Cole score. Hernandez, RVP and Welbeck with the United goals. Cole and Demel for West Ham. Come on you Reds.'
Ricky Sickelmore says via Twitter: 'I'd love to see Joe Cole score a goal on his second debut - 2-1 for me, Cole with the winner!'
De Gea, Rafael, Evans, Smalling, Vidic, Buttner, Scholes, Cleverley, Kagawa, Welbeck, Hernandez.Subs: Lindegaard, Ferdinand, Valencia, Giggs, Young, Van Persie, Macheda.
Jaaskelainen, Demel, Collins, Tomkins, Potts, Diarra, Nolan, Collison, Joe Cole, Vaz Te, C.Cole. Subs: Spiegel, Reid, Jarvis, Taylor, Noble, Spence, E.Lee.
Morgan Roberts says: 'As a United fan, this fixture worried me a bit when it was drawn (especially given our league cup defeat in 2010 at Upton Park) but United's formidable form of late should carry us through. Heard Nick Powell was injured which is a shame, as this would be an ideal platform for the youngster. 2-1 United for me.'
Ryan Simpson says: 'Both teams have good form in recent games but I think Man Utd can pull it out of the bag!'
Marcus says: 'I think this will be a good match. It will be interesting to see what team Man Utd put out but I reckon a 2-1 win for West Ham.'
In the meantime, feel free to get in touch throughout the course of Saturday evening's game. Drop me a line at firstname.lastname@example.org or via Twitter @SkySportsPeteF. A selection of the best comments will be published.
Will Joe Cole make his West Ham debut today after on Friday re-joining his boyhood club on an 18-month deal from Liverpool? Stay with us for all the team news when the word is out.