Monaco kept up their outstanding recent form as Valere Germain scored twice in a 4-0 win over Marseille on Saturday.
Nice remain three points clear at the top of Ligue 1 after winning 1-0 at Saint-Etienne on Sunday, as Marseille beat Caen.
Monaco trimmed Nice's lead at the top of Ligue 1 to three points as Leonardo Jardim's side thrashed Nancy 6-0.
Monaco missed the chance to close the gap on Ligue 1 leaders Nice while Alexandre Lacazette scored twice for Lyon.
Lyon's alarming slump in form continued on Saturday as they lost 3-1 at home to Guingamp.
Monaco moved to the top of Ligue 1 after coming from behind to beat Angers 2-1 while Lyon were upset by Lorient.