Monaco kept up their outstanding recent form as Valere Germain scored twice in a 4-0 win over Marseille on Saturday.
Nice remain three points clear at the top of Ligue 1 after winning 1-0 at Saint-Etienne on Sunday, as Marseille beat Caen.
Monaco trimmed Nice's lead at the top of Ligue 1 to three points as Leonardo Jardim's side thrashed Nancy 6-0.
Monaco missed the chance to close the gap on Ligue 1 leaders Nice while Alexandre Lacazette scored twice for Lyon.
Lyon's alarming slump in form continued on Saturday as they lost 3-1 at home to Guingamp.
Monaco moved to the top of Ligue 1 after coming from behind to beat Angers 2-1 while Lyon were upset by Lorient.
Mario Balotelli scored twice as Nice beat Monaco 4-0 to go top of Ligue 1, while there were also wins for Lyon and Bordeaux.
Thomas Lemar fired a late double as Monaco moved three points clear of PSG at the top of Ligue 1 with a 3-0 win against Rennes.
Monaco returned to the top of the Ligue 1 table thanks to a thumping 4-1 win in Lille on Saturday.
Alexandre Lacazette was forced off with a knee injury as Lyon slipped up to Dijon, while Nice were held by Lille.
Bordeaux beat Saint-Etienne, while newly-promoted Metz came from behind to beat Lille. Get the latest from Ligue 1...
Jocelyn Gourvennec has left Guingamp to take over as Bordeaux's new head coach.
Lyon secured a Champions League place for next season after thrashing Monaco 6-1 at Parc Olympique Lyonnais.
Lyon and Monaco made it seemingly a two-horse race for second place in Ligue 1 with wins on Saturday.
Monaco missed the chance to return to second place in Ligue 1 after conceding a late goal to draw 1-1 at Rennes.
Monaco beat out-of-form Marseille 2-1 at Stade Louis II to move back into second place above Lyon in Ligue 1.
PSG rested their big guns ahead of Tuesday's crunch Champions League trip to Manchester City - but still won 2-0 at Guingamp on Saturday in Ligue 1.
Marseille lost more ground in their bid to play in Europe next season as a 1-1 draw at Lorient extended their winless run in Ligue 1 to six games.
Rennes recorded an emphatic 4-1 victory over Nantes on Sunday, while Lyon went one better with a 5-1 win over Guinhamp.
Former champions Montpellier moved further clear of relegation trouble in Ligue 1 on Saturday with a 3-0 win against Lille.