ADO Den Haag and Heerenveen will join Vitesse and Utrecht in the play-offs for the last Europa League spot despite mixed fortunes on the final day.
Former Eredivisie champions FC Twente have been relegated from the league after a thumping 5-0 defeat at Vitesse on Sunday.
Jorrit Hendrix's impressive late strike earned a point for Dutch champions PSV Eindhoven in a 2-2 draw against Roda.
Heracles clinched a third successive win to move into the top half of the Eredivisie as they hit back from a goal down to edge out Twente.
AZ Alkmaar kept the pressure on second-placed Ajax by coming from behind to beat the Eredivisie's bottom club Sparta Rotterdam 2-1.
Ajax closed the gap on Eredivisie leaders PSV Eindhoven to five points with a 1-0 win at PEC Zwolle on Sunday.
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