Go Ahead Eagles can only strive for a play-off place in their unlikely bid to avoid relegation after they were beaten 3-2 by Groningen.
Ajax thrashed NEC Nijmegen 5-1 to move level on points with Eredivisie leaders Feyenoord on Saturday.
Jens Toornstra scored a hat-trick as Eredivisie leaders Feyenoord thrashed struggling Go Ahead Eagles 8-0.
PSV Eindhoven moved up to second place in the Eredivisie after a 2-0 win at Sparta Rotterdam.
PSV Eindhoven beat Vitesse 1-0 to close the gap on second-placed Ajax to a point and move five behind leaders Feyenoord.
ADO Den Haag boosted their hopes of survival in the Eredivisie with a 1-0 home victory against NEC on Saturday.