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Chelsea's trip to United on Sunday will be a key encounter in the race for the title, with just three points separating Carlo Ancelotti's men from the Premier League leaders with only three games remaining.
Both sides have everything to play for at Old Trafford, with precious points up for grabs and silverware at stake.
All eyes are likely to be on the heavyweights for Sunday's showdown, just as they were when the two collided in the UEFA Champions League last month, with the Blues coming off worse in that tie.
United and Chelsea have produced more than their fair share of unforgettable encounters during the modern era, and skysports.com here counts down ten of the most memorable.
United shook Chelsea's title ambitions with a comprehensive demolition of their old adversaries at Old Trafford, while the result piled the pressure on then manager Luiz Felipe Scolari, who was shown the door soon after. The Blues were completely outclassed as goals from Nemanja Vidic, Wayne Rooney and Dimitar Berbatov took them apart, leaving them trailing leaders Liverpool in the hunt for the title. With the Blues vanquished, United went on to pip the Merseysiders to the crown.
It seems unlikely United and Chelsea will ever play a more dramatic or crucial game against each other than the one that transpired in Moscow in 2008. With UEFA Champions League glory hanging in the balance, Cristiano Ronaldo put the Red Devils ahead in the first half, but a Frank Lampard equaliser took the clash into extra time. There was more drama as Didier Drogba was sent off for the Blues before the encounter went to penalties, which United won 6-5 after John Terry and Nicolas Anelka fluffed their lines from the spot.
The Blues snatched victory at Stamford Bridge to add some late spice to the title race just a month before their Moscow misery. Before the match, United were three points ahead with just three games remaining, but Chelsea refused to give up without a fight. Michael Ballack opened the scoring on the stroke of half-time, but Wayne Rooney came back for the visitors soon after the break. The encounter looked destined for a draw until Ballack converted from the spot with four minutes remaining to keep the title race alive - although United eventually clinched the trophy by two points. The game became know as 'The Battle of Stamford Bridge' after Patrice Evra and members of the Chelsea ground staff came to blows after the clash.
This clash might have lacked the thrill-factor that was expected, being the first final at the new Wembley Stadium, but it was a compelling tussle as the Blues bid for their first FA Cup title in seven years. The encounter remained locked in a stalemate at the end of the 90 minutes after neither side managed to land the knockout blow. Extra-time was similarly uneventful until Didier Drogba did what he does best; notching the only goal of the game late into the added minutes to hand the West Londoners the silverware.
The Blues ruthlessly asserted their domestic dominance over United with this comprehensive win to pick up their second successive Premier League crown back in 2006. Jose Mourinho's men needed only a point to put the seal on another title triumph, and William Gallas set them on their way with a fifth-minute header. Joe Cole added a superb individual goal on the hour and Ricardo Carvalho fired home Chelsea's third to allow them to stroll across the finish line. One notable dampener on the clash was a broken metatarsal suffered by Wayne Rooney, which threatened to keep him out of the impending World Cup finals.
Both sides were gunning for the Premier League title before the season kicked off but Chelsea entered this clash with just one victory from their first six games. That did not stop Jimmy Floyd Hasselbaink finding the opener after seven minutes, but Chelsea's joy was short-lived as Paul Scholes, Teddy Sheringham and David Beckham all replied for the hosts in the first half. The Blues needed to pull something out of the bag if they wanted to salvage a share of the spoils and Norwegian hitman Tore Andre Flo turned out to be their rescuer, netting a second-half brace to clinch a point.
No one could have predicted this thrashing following United's treble-winning heroics from the previous season, and they travelled to Stamford Bridge in October on a 29-game unbeaten run. However, it took less than 60 seconds for Gustavo Poyet to pounce for the opener, before a second from Chris Sutton after 16 minutes had United's backs against the wall. The Blues wrapped up their win with another effort from Poyet, an own-goal from Henning Berg and a last-gasp strike from Jody Morris, sending the Red Devils back to Old Trafford with their tails firmly between their legs.
United could have ended up red-faced in this encounter after going 5-0 up at Stamford Bridge before unwisely taking their foot off the gas. David Beckham had got things rolling for the visitors with a first-half brace before Andy Cole struck twice either side of the break. Teddy Sheringham looked to have put the final nail in Chelsea's coffin 16 minutes from time - but that was before the Red Devils went into complete meltdown. Graeme la Saux sparked the Chelsea revival by pulling one back for the hosts, then two quickfire strikes from Gianluca Vialli helped add some credibility to the final scoreline. Despite the scare it was United that progressed and the Blues that crashed out of the cup at the first hurdle.
United were on target with another glut of goals at Stamford Bridge in October 1995, with Paul Scholes grabbing the first two of the game inside the opening nine minutes. The Red Devils sat comfortably on their lead until Mark Hughes offered Chelsea some hope 12 minutes from time with a late goal, but further efforts from Ryan Giggs and Brian McClair ensured there were no upsets and helped pave the way for Ferguson's men to reclaim the top-flight crown.
This one-sided final at Wembley saw United wrap up a much-coveted league and FA Cup double in emphatic style. The Blues held firm for an hour before United kicked things up a gear, with Eric Cantona sending Dmitri Kharine the wrong way from the penalty spot in the 60th minute before replicating his effort from 12 yards six minutes later. Mark Hughes added another with 21 minutes left on the clock before Brian McClair tapped home late on to complete the thrashing and crown United champions.
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