Graeme Smith struck a match-winning 103 not out as South Africa breezed to a nine-wicket win over Bangladesh in the opening one-day international in Chittagong.
Smith and Herschelle Gibbs shared a hundred partnership as the Proteas chased down the Tigers' target of 178 with 13 overs remaining.
Andre Nel starred with the ball for the tourists as he claimed his 100th ODI victim on the way to figures of 3-24 -Tamim Iqbal the only batsman to offer any resistance as he struck a brisk 82.
With Mark Boucher, Jacques Kallis, Makhaya Ntini and Dale Steyn all rested following the Test series whitewash, things seemed to be going the hosts' way as Mohammed Ashraful won the toss and elected to bat.
However, it took the South African attack just eight overs to find the breakthrough as Junaid Siddique got his pull shot all wrong and Charl Langeveldt claimed his first wicket of the day.
Nel got in on the act soon after as he made Shahriar Nafees his 100th ODI victim after the left-hander edged to a gleeful AB de Villiers behind the stumps.
Ashraful and Saqibul Hasan fell in quick succession as the Tigers innings slumped to 89-4 at the halfway stage.
Iqbal stood firm and went past 50 as he attempted to bring some respectability to the total.
The aggressive opener looked set for his maiden one-day century, but the introduction of Paul Harris into the attack proved to be the left-hander's undoing.
It was a case of one shot too many as Iqbal picked out Albie Morkel on the mid-on boundary to effectively end any hopes of the Tigers amassing a competitive total.
The lower order failed to wag, and with only 57 runs added for the last five wickets - the Tigers innings went out with a whimper as they ended on 178.
In response Smith and Gibbs quickly found their rhythm against Bangladesh's less than potent attack.
The Proteas skipper has taken a likening to the Chittagong surface - he went past 50 to add to his majestic double-hundred he scored at the same ground in the recent second Test.
Gibbs brought up his half-century in style soon after as he clinically dispatched Mosharraf Hossain over extra cover.
The right-handed opener's dismissal was the only blemish in an otherwise flawless chase. Gibbs perished for 57 after he was trapped in front by Saqibul with the score on 143.
Hashim Amla joined Smith as the Proteas skipper led the way with a flurry of boundaries as the tourists edged ever closer to the target.
Smith completed his ton and put his side one up in the three-match series as he marched down the pitch to Saqibul and dispatched the medium-pacer over mid-on.