Hampshire will be without England pair Kevin Pietersen and Michael Lumb when they bid to lift the Friends Provident t20 trophy on home soil at the Rose Bowl on Saturday.
The Royals, making their maiden appearance on finals day, take on Essex Eagles in the first semi-final - coverage starts on Sky Sports HD1/1 from 11am.
But their hopes of becoming the first county to win the domestic T20 competition on home soil in its eight-year history suffered a blow when Lumb - who opened for England during their World T20 victory in May - broke his foot while fielding against Somerset on Thursday.
Lumb's absence, coupled with the decision not to consider Pietersen because he is leaving the county at the end of the season, means Hampshire are putting their faith in youngsters such as James Vince and Danny Briggs, who both impressed during the group stage.
Skipper Dominic Cork and all-rounder Sean Ervine are each receiving treatment for back injuries but are expected to be fit, while Australian Daniel Christian is recovering from being hit in the face by a Zander de Bruyn bouncer at Taunton.
Hampshire do, however, boast the leading run scorer in this year's competition in the shape of opening batsman Jimmy Adams.
"I'm looking forward to tomorrow and hopefully I can contribute," Adams, who has scored 600 runs in 17 innings, told Sky Sports News.
"If we get two wins that will be even better and if I can score some runs on the way then great.
"The guys are pretty excited and, when we turn up and hear the buzz of the crowd, the adrenalin will be flowing."
On Lumb's absence, he admitted: "It's a great shame. Lumb had come back into some serious form and was hitting the ball beautifully.
"To lose him is annoying but saves a selection headache for the management."
Bravo jets in
Essex have signed West Indies all-rounder Dwayne Bravo just for the day and also have leg-spinner Danish Kaneria at their disposal after he was dropped from Pakistan's squad.
England Test opener Alastair Cook has been made available by the ECB and, despite his recent poor form, is a certain starter, while South African-born Dutch all-rounder Ryan ten Doeschate is could return after a near two-month lay-off with a torn calf muscle.
The Eagles are without fast bowler Maurice Chambers due to a side strain and Andy Carter, who is on loan from Nottinghamshire, is struggling with a stiff back.
Nottinghamshire play Somerset in the second semi-final and, should they progress to meet Essex in the final, Carter would not be able to play due to "gentleman's agreement" between the counties.