James Tomlinson took 4-23 as Leicestershire were asked to follow-on by Hampshire on day two of their LV= County Championship Division Two match.
The left=arm seamer exploited good conditions to help dismiss the Foxes for 143 in response to the hosts' first innings total of 454-7 declared.
Openers Michael Thornely and Niall O'Brien had to bat out the last two overs of the day without scoring when following on but the damage had already been done.
Thornely and O'Brien gave no hint of the tribulations to come with an opening stand of 31 but when Wood had O'Brien caught at first slip by Ervine, the batting was processional.
Tomlinson's first victim was Thornely, followed in rapid succession by Ned Eckersley and Josh Cobb to make inexperienced Leicestershire 64-4, a position from which they never recovered.
Only captain Ramnaresh Sarwan hung around long enough to make an impression, hitting five fours in his top score of 25 before he was bowled by Sean Ervine.
At 118-9 Leicestershire looked doomed but then last pair Matthew Hoggard and Alex Wyatt attempted to bring some respectability to the score with an aggressive stand of 25 before Tomlinson returned to have Hoggard edge to third slip.
Earlier Hampshire had resumed on 286-4 and had little difficulty in adding a further 168 in 39 overs for the loss of Ervine, James Vince and Chris Wood.
Ervine fell for 69 but Vince (148) was in imperious form, reaching his century with his 17th boundary off Shiv Thakor as Hampshire built a formidable total.
Vince and newcomer Adam Wheater added 104 for the sixth wicket in 29 overs while the latter blasted a rapid unbeaten 56 and Wood took advantage of a demoralized attack to make a swift 28.