Lancashire will welcome back James Anderson for their first home match in the LV County Championship.
The seamer sat out the rain-hit draw with Surrey last week after returning home from England's tour of New Zealand.
His return to county action is timely for the Red Rose county with Oliver Newby and Dominic Cork both sidelined.
Spinner Gary Keedy is also an injury doubt with a thigh strain but all-rounder Andrew Flintoff suffered no setbacks with his ankle at the Brit Oval as he continues his comeback after a fourth ankle operation.
Somerset are without Andy Caddick for the trip to Old Trafford.
The veteran seam bowler has yet to fully recover following back surgery in December and is not part of a 14-man squad.
The main selection decision concerns the final member of the bowling attack, with either medium pacer Ben Phillips or leg-spinner Michael Munday likely to be surplus to requirements.