Rookie spinner Simon Kerrigan bowled Lancashire to a 121-run triumph over Warwickshire on the final day at Old Trafford.
The 20-year-old, making his first-class debut after the county's senior spinner Gary Keedy broke his collarbone in pre-season, recorded figures of 5-43 as Warwickshire crashed to 197 all out chasing a target of 319.
Resuming on 52-3 on the fourth morning, the Bears initially made good progress as opener Ian Westwood and Jim Troughton extended their fourth-wicket stand to 65 before Kerrigan made his first intervention.
The left-arm spinner had Troughton caught on the run by Ashwell Prince at mid-on for 39 and then proceeded to rip the heart out of Warwickshire's middle order.
He accounted for Rikki Clarke (7), Tim Ambrose (0), Chris Woakes (0) and Naqaash Tahir (0) as the visitors went to lunch at 161-9.
Westwood and Imran Tahir resisted for almost nine overs of the afternoon session before Sajid Mahmood (2-65) had Tahir (36) caught by Prince to bring an end to proceedings.
Warwickshire skipper Westwood, who carried his bat for 82 off 194 balls, has now overseen consecutive defeats to start the season, while Lancashire made a winning start to their bid for a first outright County Championship title since 1934.
Sajid Mahmood and Glen Chapple shared a 10th-wicket partnership of 77 inside 12 overs to help Lancashire set Warwickshire a daunting 319 for victory at Old Trafford.
Former England Test number eight Mahmood recorded his first half-century for Lancashire since 2005 and Chapple (53 not out) reached his second of this Division One fixture to boost the hosts to a second-innings total of 319.
Mahmood then added the prized wicket of England batsman Ian Bell, lbw for nine, and Tom Smith trapped Jonathan Trott in front for six as Warwickshire slumped to 34 for three in their chase. They closed day three on 52 for three from 29 overs, requiring a further 267 runs for victory.
Mahmood hit a total of nine fours and that maximum while Chapple thumped four fours and a six. The former was the last man out when caught at short leg by Varun Chopra off Imran.
Former Essex man Chopra was soon in the action again as the first man out in Warwickshire's second innings when he was trapped lbw by Chapple in the sixth over for six.
And Lancashire knew they were on top when man of the moment Mahmood and Smith got key duo Bell and Trott before the 22nd over was up.
With the ball moving prodigiously early on each day's play so far, Ian Westwood (24 not out) and Jim Troughton must navigateSunday's first hour if their side are to play any part in the match.
Lancashire and Warwickshire head into the third day with their LV= County Championship Division One match fascinatingly poised at Old Trafford.
After dismissing the Red Rose county for 253 the previous day, Warwickshire amassed just one run more in their first-innings.
England seamer James Anderson marked his return to action after missing the recent tour of Bangladesh with 2-62 from 20 probing overs.
And ironically Anderson, who was bowled by England team-mate Jonathan Trott for a duck on day one, returned the punishment by clean bowling the Warwickshire batsman when the pair resumed battle.
Fellow England man Ian Bell top-scored for the Bears with 47 and James Troughton (44) and Rikki Clarke (43) also chipped in.
Then, with the game moving along quickly, Lancashire reached stumps on 84-2 with new signing Stephen Moore (43 not out), well set.
Chris Woakes made an explosive start at Old Trafford with three quick wickets helping restrict Lancashire to 253 in their first innings against Warwickshire.
Young seamer Woakes ripped through the Red Rose county's top order, removing opener Tom Smith for a third-ball duck before Paul Horton and Stephen Moore followed.
From 9-3, Lancashire slipped further when Mark Chilton went for three to leave the hosts languishing on 14-4, and they needed the staunch resistance of Ashwell prince to dig them out of trouble.
The South African made 82, while Steven Croft added 64 as the two combined for a fifth-wicket stand of 133 that got the hosts back into the game.
Glen Chapple added 54 not out as Lancashire got their score someway towards respectability, and Warwickshire slipping to 13-1 with a late wicket in just eight overs will give them some hope.